CRCGN009_HEPG2_24H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN009_HEPG2_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.21922
EPHB2 EPH receptor B2 8.49566
CXCR4 chemokine (C-X-C motif) receptor 4 7.79403
MAP7 microtubule-associated protein 7 7.15118
PPARG peroxisome proliferator-activated receptor gamma 5.75511
MINDY1 MINDY lysine 48 deubiquitinase 1 5.15502
BZW2 basic leucine zipper and W2 domains 2 4.89929
CBR3 carbonyl reductase 3 4.84472
C2CD2 C2 calcium-dependent domain containing 2 4.68231
STK10 serine/threonine kinase 10 4.13629
ATP11B ATPase, class VI, type 11B 4.04224
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.7584
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.64582
ANKRD36C ankyrin repeat domain 36C 3.2732
CHN1 chimerin 1 3.22924
CDX1 caudal type homeobox 1 3.1335
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.98489
SNAP25 synaptosomal-associated protein, 25kDa 2.97742
DACH1 dachshund family transcription factor 1 2.90624
LIPG lipase, endothelial 2.78534
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.77936
HLA-DRA major histocompatibility complex, class II, DR alpha 2.73757
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.73332
PLAGL1 pleiomorphic adenoma gene-like 1 2.70282
GARRE1 granule associated Rac and RHOG effector 1 2.56369
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.54066
CNPY3 canopy FGF signaling regulator 3 2.49156
CLASRP CLK4-associating serine/arginine rich protein 2.4152
LRRC32 leucine rich repeat containing 32 2.40779
GPER1 G protein-coupled estrogen receptor 1 2.40606
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.37471
PCSK7 proprotein convertase subtilisin/kexin type 7 2.3651
PLD2 phospholipase D2 2.35919
INSM1 insulinoma-associated 1 2.34199
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.31643
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.30954
MISP mitotic spindle positioning 2.3026
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.26679
ZNF589 zinc finger protein 589 2.25293
AGTR1 angiotensin II receptor, type 1 2.14704
CCDC88A coiled-coil domain containing 88A 2.13174
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.12837
CEND1 cell cycle exit and neuronal differentiation 1 2.12118
SPOUT1 SPOUT domain containing methyltransferase 1 2.09903
MYBPH myosin binding protein H 2.09228
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.08929
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.0862
DIPK1A divergent protein kinase domain 1A 2.07925
NOX1 NADPH oxidase 1 2.06966
GSTT1 glutathione S-transferase theta 1 2.06797
BPIFA1 BPI fold containing family A, member 1 2.06571
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.05891
CORO2B coronin, actin binding protein, 2B 2.05853
FKBP10 FK506 binding protein 10, 65 kDa 2.02335
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.02029
MTA2 metastasis associated 1 family, member 2 2.01195
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.00084

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.18298
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.27781
ZMIZ1 zinc finger, MIZ-type containing 1 -5.79888
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.42124
THAP11 THAP domain containing 11 -4.94415
FASTKD5 FAST kinase domains 5 -4.91414
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.80423
FAIM Fas apoptotic inhibitory molecule -4.7898
DERA deoxyribose-phosphate aldolase (putative) -4.184
TM9SF3 transmembrane 9 superfamily member 3 -4.12105
CCNH cyclin H -3.90041
CHMP4B charged multivesicular body protein 4B -3.86725
HMG20B high mobility group 20B -3.84459
CCDC86 coiled-coil domain containing 86 -3.76201
ZNF586 zinc finger protein 586 -3.36308
TCTN1 tectonic family member 1 -3.32455
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.11799
TMEM186 transmembrane protein 186 -3.03759
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.90399
CSK c-src tyrosine kinase -2.85984
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.83883
RIPK4 receptor-interacting serine-threonine kinase 4 -2.72818
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.70404
MRTFB myocardin related transcription factor B -2.6709
PRR13 proline rich 13 -2.65691
ERCC6L excision repair cross-complementation group 6-like -2.53071
IFT38 intraflagellar transport 38 -2.43433
IER2 immediate early response 2 -2.42592
LAPTM4A lysosomal protein transmembrane 4 alpha -2.42531
HOXA1 homeobox A1 -2.3983
CCNC cyclin C -2.37151
THUMPD1 THUMP domain containing 1 -2.31929
CDIP1 cell death-inducing p53 target 1 -2.26357
HAX1 HCLS1 associated protein X-1 -2.16661
DOK4 docking protein 4 -2.15325
SEPHS2 selenophosphate synthetase 2 -2.14216
SPEG SPEG complex locus -2.13092
DBN1 drebrin 1 -2.13066
GCC1 GRIP and coiled-coil domain containing 1 -2.12429
LIPF lipase, gastric -2.12305
SCRG1 stimulator of chondrogenesis 1 -2.10603
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.09656
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.09052
BCKDK branched chain ketoacid dehydrogenase kinase -2.08061
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.06352
GFRA1 GDNF family receptor alpha 1 -2.05279
MOCS2 molybdenum cofactor synthesis 2 -2.04993
ATF5 activating transcription factor 5 -2.01104