CRCGN009_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN009_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.54467
GPER1 G protein-coupled estrogen receptor 1 4.85563
E2F2 E2F transcription factor 2 4.61756
CIAO3 cytosolic iron-sulfur assembly component 3 4.48964
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.26356
LPAR2 lysophosphatidic acid receptor 2 4.07448
MAP7 microtubule-associated protein 7 3.79791
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.73645
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.30458
EPHA3 EPH receptor A3 3.30354
NOTCH1 notch 1 3.19559
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.09307
ABHD6 abhydrolase domain containing 6 2.98462
BACE2 beta-site APP-cleaving enzyme 2 2.79933
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.7228
JADE2 jade family PHD finger 2 2.50606
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.42542
GSTZ1 glutathione S-transferase zeta 1 2.2048
SFTPB surfactant protein B 2.07423
HLA-DMA major histocompatibility complex, class II, DM alpha 2.06978

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.60418
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.11741
TRIB3 tribbles pseudokinase 3 -4.62909
GDF15 growth differentiation factor 15 -4.56784
CCNB2 cyclin B2 -4.36732
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.15049
OXA1L oxidase (cytochrome c) assembly 1-like -4.0566
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.99374
TM9SF3 transmembrane 9 superfamily member 3 -3.67889
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.65385
NGRN neugrin, neurite outgrowth associated -3.48416
CDC20 cell division cycle 20 -3.34275
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9849
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.85674
VAT1 vesicle amine transport 1 -2.65263
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.39317
PRPF4 pre-mRNA processing factor 4 -2.22586
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.1431
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.11922
HEATR1 HEAT repeat containing 1 -2.1084