CRCGN009_HEPG2_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrotoluene 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN009_HEPG2_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 4.84497
RPL39L ribosomal protein L39-like 4.20637
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.0459
BZW2 basic leucine zipper and W2 domains 2 3.91224
CHMP6 charged multivesicular body protein 6 3.90811
PPARG peroxisome proliferator-activated receptor gamma 3.55049
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.54169
UBQLN2 ubiquilin 2 3.02573
HLA-DMA major histocompatibility complex, class II, DM alpha 2.94679
CCL2 chemokine (C-C motif) ligand 2 2.84669
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.80188
CGRRF1 cell growth regulator with ring finger domain 1 2.68921
FZD7 frizzled class receptor 7 2.10719
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 2.09061
GATA3 GATA binding protein 3 2.05545
RXYLT1 ribitol xylosyltransferase 1 2.05134

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.47332
CCNB2 cyclin B2 -5.38759
NUP85 nucleoporin 85kDa -3.54069
EGF epidermal growth factor -3.41863
CSK c-src tyrosine kinase -3.21993
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.20668
EIF5 eukaryotic translation initiation factor 5 -3.11695
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.79965
YME1L1 YME1-like 1 ATPase -2.63072
PCNA proliferating cell nuclear antigen -2.61788
TRAP1 TNF receptor-associated protein 1 -2.42101
NRIP1 nuclear receptor interacting protein 1 -2.30057
BDKRB1 bradykinin receptor B1 -2.29953
RFC2 replication factor C (activator 1) 2, 40kDa -2.22055
TM9SF3 transmembrane 9 superfamily member 3 -2.17525
FBXL12 F-box and leucine-rich repeat protein 12 -2.10525
GNAS GNAS complex locus -2.1018
ZNF586 zinc finger protein 586 -2.063