| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 9-ethyl-9h-carbazol-3-amine hydrochloride 20.26 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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58 genes differentially expressed following the CRCGN009_HEPG2_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 6.19958 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.88357 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.5517 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.49752 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 3.32516 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.30625 |
| PRKCH | protein kinase C, eta | 3.30319 |
| E2F2 | E2F transcription factor 2 | 3.29623 |
| NOTCH1 | notch 1 | 3.17674 |
| IDE | insulin-degrading enzyme | 3.07874 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.0667 |
| TBPL1 | TBP-like 1 | 2.77805 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.64799 |
| PMM2 | phosphomannomutase 2 | 2.57316 |
| STXBP2 | syntaxin binding protein 2 | 2.52522 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.42998 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.33284 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 2.29155 |
| WDR7 | WD repeat domain 7 | 2.26783 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.25694 |
| H2BC12 | H2B clustered histone 12 | 2.21919 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.21852 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 2.15172 |
| MCM3 | minichromosome maintenance complex component 3 | 2.10847 |
| PLSCR1 | phospholipid scramblase 1 | 2.06142 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 2.04866 |
| TP53 | tumor protein p53 | 2.04002 |
| MELK | maternal embryonic leucine zipper kinase | 2.03784 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -6.93887 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -6.83523 |
| PCNA | proliferating cell nuclear antigen | -6.24798 |
| TLCD3A | TLC domain containing 3A | -5.56776 |
| FGFR4 | fibroblast growth factor receptor 4 | -5.42937 |
| PLK1 | polo-like kinase 1 | -3.74666 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.66473 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.39227 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.30543 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.29805 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.25616 |
| RPIA | ribose 5-phosphate isomerase A | -3.18697 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.07863 |
| CCNB2 | cyclin B2 | -2.99593 |
| ADI1 | acireductone dioxygenase 1 | -2.94372 |
| NGRN | neugrin, neurite outgrowth associated | -2.77855 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.70932 |
| SNX11 | sorting nexin 11 | -2.6053 |
| TLR4 | toll-like receptor 4 | -2.60366 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.58979 |
| PRPF4 | pre-mRNA processing factor 4 | -2.52133 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.38865 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.33755 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.30578 |
| YME1L1 | YME1-like 1 ATPase | -2.29244 |
| NVL | nuclear VCP-like | -2.29215 |
| BCAS4 | breast carcinoma amplified sequence 4 | -2.27112 |
| ZNF274 | zinc finger protein 274 | -2.25612 |
| TFRC | transferrin receptor | -2.24329 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.21657 |
