CRCGN009_HEPG2_24H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 9-ethyl-9h-carbazol-3-amine hydrochloride 10.13 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN009_HEPG2_24H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.48737
CYCS cytochrome c, somatic 7.42657
LCN2 lipocalin 2 7.33433
PPARG peroxisome proliferator-activated receptor gamma 6.93376
LPAR2 lysophosphatidic acid receptor 2 4.92862
ADRB2 adrenoceptor beta 2, surface 4.74442
TIAM1 T-cell lymphoma invasion and metastasis 1 4.47534
HLA-DMA major histocompatibility complex, class II, DM alpha 4.42058
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.21901
MYLK myosin light chain kinase 4.11396
STIMATE STIM activating enhancer 4.01985
TATDN2 TatD DNase domain containing 2 4.01859
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.77176
CBR3 carbonyl reductase 3 3.64849
TAC4 tachykinin 4 (hemokinin) 3.59626
BACE2 beta-site APP-cleaving enzyme 2 3.49927
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.45175
ZFP36 ZFP36 ring finger protein 3.39147
JADE2 jade family PHD finger 2 3.15375
AMDHD2 amidohydrolase domain containing 2 3.15362
CDPF1 cysteine-rich, DPF motif domain containing 1 3.11671
GSTZ1 glutathione S-transferase zeta 1 3.11555
UBQLN2 ubiquilin 2 3.0754
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.99736
ATP11B ATPase, class VI, type 11B 2.88638
STXBP1 syntaxin binding protein 1 2.65214
PLSCR1 phospholipid scramblase 1 2.58865
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.54606
SNAP25 synaptosomal-associated protein, 25kDa 2.53691
VGLL4 vestigial-like family member 4 2.4997
MAP7 microtubule-associated protein 7 2.49661
VAV3 vav 3 guanine nucleotide exchange factor 2.42382
CCL2 chemokine (C-C motif) ligand 2 2.3657
AFG3L2 AFG3-like AAA ATPase 2 2.23482
NT5C2 5'-nucleotidase, cytosolic II 2.21322
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.19993
TMEM147 transmembrane protein 147 2.1575
RRAGA Ras-related GTP binding A 2.13406
PEX11A peroxisomal biogenesis factor 11 alpha 2.13352
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.10048
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.09842
NLRP2B NLR family pyrin domain containing 2B 2.09253
STXBP2 syntaxin binding protein 2 2.08967
ANO1 anoctamin 1, calcium activated chloride channel 2.07633
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.07621
GAB2 GRB2-associated binding protein 2 2.07072
FNBP1L formin binding protein 1-like 2.06332
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.04554
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.02233

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -10.0
CCNB2 cyclin B2 -6.60003
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.57018
TLCD3A TLC domain containing 3A -4.46679
ISOC1 isochorismatase domain containing 1 -4.00314
RAI14 retinoic acid induced 14 -3.87411
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.59147
HYOU1 hypoxia up-regulated 1 -3.53233
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.49099
ADI1 acireductone dioxygenase 1 -3.46761
PCNA proliferating cell nuclear antigen -3.45992
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.39191
PUF60 poly-U binding splicing factor 60KDa -3.34161
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.15678
ZNF7 zinc finger protein 7 -3.15064
ZMIZ1 zinc finger, MIZ-type containing 1 -3.13049
LDHD lactate dehydrogenase D -2.70374
CTNND1 catenin (cadherin-associated protein), delta 1 -2.68324
NVL nuclear VCP-like -2.50247
PRPF4 pre-mRNA processing factor 4 -2.33129
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.31133
CHMP4B charged multivesicular body protein 4B -2.30177
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.30141
SCAND1 SCAN domain containing 1 -2.28416
H2AC7 H2A clustered histone 7 -2.24071
TRIB1 tribbles pseudokinase 1 -2.22543
HMG20B high mobility group 20B -2.13401
ZW10 zw10 kinetochore protein -2.09386
PDZD2 PDZ domain containing 2 -2.0926
HEATR1 HEAT repeat containing 1 -2.07066
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.06621