| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | auramine-o 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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171 genes differentially expressed following the CRCGN009_HEPG2_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 9.68592 |
| INPP1 | inositol polyphosphate-1-phosphatase | 6.2374 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 4.47302 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.2621 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 4.16584 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.07707 |
| KIFBP | kinesin family binding protein | 4.02661 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.88529 |
| H2BC12 | H2B clustered histone 12 | 3.8209 |
| CDC45 | cell division cycle 45 | 3.75803 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.73599 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 3.70398 |
| CTSL | cathepsin L | 3.66691 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.573 |
| MEF2C | myocyte enhancer factor 2C | 3.57148 |
| BLCAP | bladder cancer associated protein | 3.48117 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.45102 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 3.43725 |
| UBQLN2 | ubiquilin 2 | 3.37446 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.3072 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.26204 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.24836 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.23845 |
| LSR | lipolysis stimulated lipoprotein receptor | 3.22927 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 3.1906 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.14324 |
| CCDC92 | coiled-coil domain containing 92 | 3.08016 |
| HSPA1A | heat shock 70kDa protein 1A | 3.03732 |
| LCN2 | lipocalin 2 | 3.01435 |
| EPHA3 | EPH receptor A3 | 2.91293 |
| ABHD4 | abhydrolase domain containing 4 | 2.85819 |
| H2BC21 | H2B clustered histone 21 | 2.83556 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.82322 |
| KLHL21 | kelch-like family member 21 | 2.77612 |
| VAT1 | vesicle amine transport 1 | 2.74061 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.73804 |
| TRIB3 | tribbles pseudokinase 3 | 2.70977 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.68843 |
| SQOR | sulfide quinone oxidoreductase | 2.65499 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.62703 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.62474 |
| PLXNB2 | plexin B2 | 2.60508 |
| ANKRD10 | ankyrin repeat domain 10 | 2.60187 |
| TRAPPC6A | trafficking protein particle complex 6A | 2.58419 |
| ATP11B | ATPase, class VI, type 11B | 2.57056 |
| SQSTM1 | sequestosome 1 | 2.56651 |
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | 2.51657 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 2.48777 |
| TBPL1 | TBP-like 1 | 2.48393 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.47724 |
| STIMATE | STIM activating enhancer | 2.47535 |
| ZNF32 | zinc finger protein 32 | 2.44911 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.38169 |
| FOSL1 | FOS-like antigen 1 | 2.33554 |
| PFKL | phosphofructokinase, liver | 2.33095 |
| FEV | FEV (ETS oncogene family) | 2.32714 |
| RAP1GAP | RAP1 GTPase activating protein | 2.28464 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.25823 |
| TSC22D3 | TSC22 domain family, member 3 | 2.25062 |
| ANXA4 | annexin A4 | 2.24379 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 2.23383 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 2.18873 |
| SFTPB | surfactant protein B | 2.18863 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.18349 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.17168 |
| DOK2 | docking protein 2, 56kDa | 2.16635 |
| PCDHA9 | protocadherin alpha 9 | 2.1549 |
| ELMO2 | engulfment and cell motility 2 | 2.1527 |
| FOXO4 | forkhead box O4 | 2.13712 |
| PTK2 | protein tyrosine kinase 2 | 2.12599 |
| KIF20A | kinesin family member 20A | 2.1037 |
| SETMAR | SET domain and mariner transposase fusion gene | 2.10067 |
| SH3GL3 | SH3-domain GRB2-like 3 | 2.10048 |
| INA | internexin neuronal intermediate filament protein, alpha | 2.09636 |
| SIRT2 | sirtuin 2 | 2.08138 |
| ALX1 | ALX homeobox 1 | 2.07985 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 2.07921 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.06671 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 2.06513 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 2.0648 |
| GSTM2 | glutathione S-transferase mu 2 (muscle) | 2.06151 |
| ZNF536 | zinc finger protein 536 | 2.06079 |
| TXNRD1 | thioredoxin reductase 1 | 2.04666 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.00903 |
| DUSP3 | dual specificity phosphatase 3 | 2.00663 |
| HABP2 | hyaluronan binding protein 2 | 2.00478 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -7.72335 |
| ZW10 | zw10 kinetochore protein | -6.57667 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -6.51981 |
| MELK | maternal embryonic leucine zipper kinase | -6.43285 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -5.76586 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -5.62942 |
| CCNB2 | cyclin B2 | -5.47049 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -5.15659 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.35635 |
| TLCD3A | TLC domain containing 3A | -4.27681 |
| CDK1 | cyclin-dependent kinase 1 | -4.16953 |
| LDHD | lactate dehydrogenase D | -4.16432 |
| HMGA2 | high mobility group AT-hook 2 | -3.96556 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.86823 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.68762 |
| RSU1 | Ras suppressor protein 1 | -3.64017 |
| CDK6 | cyclin-dependent kinase 6 | -3.63949 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.56444 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.46271 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.45934 |
| WASHC4 | WASH complex subunit 4 | -3.42191 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -3.41973 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.39176 |
| NUP85 | nucleoporin 85kDa | -3.39065 |
| ADI1 | acireductone dioxygenase 1 | -3.36417 |
| PGM1 | phosphoglucomutase 1 | -3.33627 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.29998 |
| PCNA | proliferating cell nuclear antigen | -3.14498 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.10757 |
| GLOD4 | glyoxalase domain containing 4 | -3.08715 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.01841 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -3.00737 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.92126 |
| ZNF274 | zinc finger protein 274 | -2.77415 |
| ATF6 | activating transcription factor 6 | -2.69843 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.68845 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.6763 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.66442 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.64419 |
| BLMH | bleomycin hydrolase | -2.60134 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.53197 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.53119 |
| NGRN | neugrin, neurite outgrowth associated | -2.52246 |
| PFAS | phosphoribosylformylglycinamidine synthase | -2.51862 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.51064 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -2.48669 |
| ANO10 | anoctamin 10 | -2.47724 |
| CCNA2 | cyclin A2 | -2.47235 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.45101 |
| KIF11 | kinesin family member 11 | -2.4395 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -2.434 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.43259 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.4192 |
| MSH6 | mutS homolog 6 | -2.37175 |
| AURKB | aurora kinase B | -2.35757 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.35254 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.32383 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.28466 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.26591 |
| CKAP5 | cytoskeleton associated protein 5 | -2.24039 |
| MSRA | methionine sulfoxide reductase A | -2.23564 |
| PLS1 | plastin 1 | -2.21056 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.20827 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -2.20695 |
| NUCB2 | nucleobindin 2 | -2.20208 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.1956 |
| TLR4 | toll-like receptor 4 | -2.18467 |
| TTC27 | tetratricopeptide repeat domain 27 | -2.17774 |
| NFIL3 | nuclear factor, interleukin 3 regulated | -2.16718 |
| RB1 | retinoblastoma 1 | -2.15887 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.13432 |
| FIRRM | FIGNL1 interacting regulator of recombination and mitosis | -2.12463 |
| MSH2 | mutS homolog 2 | -2.11632 |
| STMN1 | stathmin 1 | -2.0827 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.07439 |
| CAAP1 | caspase activity and apoptosis inhibitor 1 | -2.06487 |
| CASP8AP2 | caspase 8 associated protein 2 | -2.06122 |
| MSMO1 | methylsterol monooxygenase 1 | -2.06121 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.06102 |
| UBE3C | ubiquitin protein ligase E3C | -2.05353 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -2.05145 |
| SCCPDH | saccharopine dehydrogenase (putative) | -2.04963 |
| HAT1 | histone acetyltransferase 1 | -2.04344 |
| KIF14 | kinesin family member 14 | -2.0432 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.01783 |
