CRCGN009_HEPG2_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description auramine-o 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN009_HEPG2_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 10.0
PPARG peroxisome proliferator-activated receptor gamma 6.57522
CDPF1 cysteine-rich, DPF motif domain containing 1 6.27554
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.2134
INPP1 inositol polyphosphate-1-phosphatase 5.00515
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.70866
BLCAP bladder cancer associated protein 4.38588
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.3468
MAP7 microtubule-associated protein 7 4.20875
KLHL21 kelch-like family member 21 4.14141
DYNLT3 dynein, light chain, Tctex-type 3 4.11816
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.09583
ABHD4 abhydrolase domain containing 4 4.02446
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.98474
CNPY3 canopy FGF signaling regulator 3 3.89886
UBQLN2 ubiquilin 2 3.82569
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.76257
H2BC12 H2B clustered histone 12 3.65897
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.51343
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.32975
TERF2IP telomeric repeat binding factor 2, interacting protein 3.18953
LCN2 lipocalin 2 3.187
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.14494
LPAR2 lysophosphatidic acid receptor 2 3.08843
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.07144
RPL39L ribosomal protein L39-like 3.04416
ADGRE5 adhesion G protein-coupled receptor E5 3.0144
ADRB2 adrenoceptor beta 2, surface 3.00407
CCP110 centriolar coiled coil protein 110kDa 2.98115
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.94099
ARID5B AT rich interactive domain 5B (MRF1-like) 2.90566
LSR lipolysis stimulated lipoprotein receptor 2.85901
BACE2 beta-site APP-cleaving enzyme 2 2.75905
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.75255
DIPK1A divergent protein kinase domain 1A 2.7085
RAB21 RAB21, member RAS oncogene family 2.67663
H2BC21 H2B clustered histone 21 2.65288
FOSL1 FOS-like antigen 1 2.64625
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.617
E2F2 E2F transcription factor 2 2.59085
PLS1 plastin 1 2.5148
SESN1 sestrin 1 2.51345
RPP38 ribonuclease P/MRP 38kDa subunit 2.48864
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.47702
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.45642
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.43591
ZDHHC11B zinc finger, DHHC-type containing 11B 2.41874
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.41346
AXIN1 axin 1 2.39281
VAT1 vesicle amine transport 1 2.3844
SFTPB surfactant protein B 2.36478
HSPB1 heat shock 27kDa protein 1 2.35437
GPKOW G patch domain and KOW motifs 2.3365
ANKRD10 ankyrin repeat domain 10 2.31444
VGLL4 vestigial-like family member 4 2.31085
ALAS1 5'-aminolevulinate synthase 1 2.29042
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.28528
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.24516
SQSTM1 sequestosome 1 2.15991
CCDC57 coiled-coil domain containing 57 2.15355
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.12785
MOK MOK protein kinase 2.11858
SLC75A1 solute carrier family 75 member 1 2.11315
ZBTB25 zinc finger and BTB domain containing 25 2.10479
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.08592
BYSL bystin-like 2.0859
TBC1D31 TBC1 domain family, member 31 2.08541
KIF3A kinesin family member 3A 2.083
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.07223
DOCK5 dedicator of cytokinesis 5 2.06402
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.03395
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.02118
BMP10 bone morphogenetic protein 10 2.02055
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.00287

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.92479
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.92332
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.77068
PCNA proliferating cell nuclear antigen -6.56252
SLC35F2 solute carrier family 35, member F2 -6.34246
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.15805
MELK maternal embryonic leucine zipper kinase -6.07564
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.46453
VDAC1 voltage-dependent anion channel 1 -5.1178
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.11145
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.85452
TOP2A topoisomerase (DNA) II alpha 170kDa -4.41593
RSU1 Ras suppressor protein 1 -4.40126
NT5DC2 5'-nucleotidase domain containing 2 -4.34115
HMGA2 high mobility group AT-hook 2 -4.10226
ZMIZ1 zinc finger, MIZ-type containing 1 -4.01084
RFC2 replication factor C (activator 1) 2, 40kDa -3.99479
CSK c-src tyrosine kinase -3.96385
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.79383
PCCB propionyl CoA carboxylase, beta polypeptide -3.6679
LDHD lactate dehydrogenase D -3.66265
SNX11 sorting nexin 11 -3.5001
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.47845
CDK1 cyclin-dependent kinase 1 -3.35702
CCNB1 cyclin B1 -3.27743
DERA deoxyribose-phosphate aldolase (putative) -3.21648
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.16034
NRIP1 nuclear receptor interacting protein 1 -3.10153
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.09773
ZW10 zw10 kinetochore protein -3.09255
TCTN1 tectonic family member 1 -3.03477
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.02829
HYOU1 hypoxia up-regulated 1 -2.77733
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.70833
PGM1 phosphoglucomutase 1 -2.67264
FHL2 four and a half LIM domains 2 -2.51551
MYLK myosin light chain kinase -2.49569
AURKB aurora kinase B -2.49164
HADH hydroxyacyl-CoA dehydrogenase -2.46146
CCNB2 cyclin B2 -2.39493
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.39245
STMN1 stathmin 1 -2.38949
PHKB phosphorylase kinase, beta -2.37016
PSRC1 proline/serine-rich coiled-coil 1 -2.35558
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.331
UBE2C ubiquitin-conjugating enzyme E2C -2.31956
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.30665
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.28045
NUCB2 nucleobindin 2 -2.27884
ANO10 anoctamin 10 -2.26405
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.24988
NNT nicotinamide nucleotide transhydrogenase -2.20333
KDM3A lysine (K)-specific demethylase 3A -2.15351
BIRC2 baculoviral IAP repeat containing 2 -2.12827
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.08072
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.02606
MSRA methionine sulfoxide reductase A -2.021