CRCGN009_HEPG2_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description auramine-o 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN009_HEPG2_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.64615
CIAO3 cytosolic iron-sulfur assembly component 3 6.47825
SNAP25 synaptosomal-associated protein, 25kDa 5.35355
LCN2 lipocalin 2 4.82435
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.54418
BLCAP bladder cancer associated protein 4.32699
INPP1 inositol polyphosphate-1-phosphatase 4.32645
CNPY3 canopy FGF signaling regulator 3 4.25515
H2BC12 H2B clustered histone 12 4.12822
GPER1 G protein-coupled estrogen receptor 1 3.75057
UBQLN2 ubiquilin 2 3.55824
CHN1 chimerin 1 3.39697
CDC45 cell division cycle 45 3.25908
RRAGA Ras-related GTP binding A 3.15875
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.0977
CDK7 cyclin-dependent kinase 7 2.97023
FOSL1 FOS-like antigen 1 2.90907
EPHB2 EPH receptor B2 2.89812
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.88154
STIMATE STIM activating enhancer 2.85571
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.84895
DDB2 damage-specific DNA binding protein 2, 48kDa 2.79868
MAMLD1 mastermind-like domain containing 1 2.78463
ABHD4 abhydrolase domain containing 4 2.65969
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.54365
SESN1 sestrin 1 2.49417
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.4889
CYCS cytochrome c, somatic 2.39332
FPGS folylpolyglutamate synthase 2.37518
EGF epidermal growth factor 2.37143
RXYLT1 ribitol xylosyltransferase 1 2.35467
TRIB1 tribbles pseudokinase 1 2.3124
MVP major vault protein 2.25419
GPC1 glypican 1 2.24982
GATA2 GATA binding protein 2 2.23347
TERF2IP telomeric repeat binding factor 2, interacting protein 2.20589
HDGFL3 HDGF like 3 2.16702
ABHD6 abhydrolase domain containing 6 2.14791
DOK7 docking protein 7 2.14287
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.12847
NINL ninein-like 2.07434
VAT1 vesicle amine transport 1 2.06793
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.03506
SFTPB surfactant protein B 2.02614
ALOX15B arachidonate 15-lipoxygenase, type B 2.0209
CCP110 centriolar coiled coil protein 110kDa 2.00887

decreased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase -4.99935
HYOU1 hypoxia up-regulated 1 -4.46959
AURKB aurora kinase B -4.3249
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.04849
CDK1 cyclin-dependent kinase 1 -3.91287
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.91092
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.87165
TCTN1 tectonic family member 1 -3.85916
TLCD3A TLC domain containing 3A -3.74883
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.64213
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.55142
NGRN neugrin, neurite outgrowth associated -3.40418
TOP2A topoisomerase (DNA) II alpha 170kDa -3.37888
OXA1L oxidase (cytochrome c) assembly 1-like -3.33409
CCNB1 cyclin B1 -3.238
NRIP1 nuclear receptor interacting protein 1 -3.17833
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.16552
TLR4 toll-like receptor 4 -3.13951
LDHD lactate dehydrogenase D -3.13023
FAIM Fas apoptotic inhibitory molecule -3.0489
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.95197
ANO10 anoctamin 10 -2.93134
NPC1 Niemann-Pick disease, type C1 -2.86903
EIF5 eukaryotic translation initiation factor 5 -2.83935
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.82562
DNM1L dynamin 1-like -2.72777
PSRC1 proline/serine-rich coiled-coil 1 -2.65884
PCNA proliferating cell nuclear antigen -2.61123
ICAM3 intercellular adhesion molecule 3 -2.60405
CSK c-src tyrosine kinase -2.56649
MSRA methionine sulfoxide reductase A -2.5616
PGM1 phosphoglucomutase 1 -2.56024
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.49868
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.48904
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.45594
HADH hydroxyacyl-CoA dehydrogenase -2.43303
RSU1 Ras suppressor protein 1 -2.37265
NUCB2 nucleobindin 2 -2.33512
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.27696
BIRC2 baculoviral IAP repeat containing 2 -2.27156
DCK deoxycytidine kinase -2.2202
STAMBP STAM binding protein -2.2025
NUP85 nucleoporin 85kDa -2.14167
PDE5A phosphodiesterase 5A, cGMP-specific -2.12827
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.12751
PLK1 polo-like kinase 1 -2.11756
CCNA2 cyclin A2 -2.11252
DENND2D DENN/MADD domain containing 2D -2.10001
GNAS GNAS complex locus -2.07691
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.04969
FOXM1 forkhead box M1 -2.04089
HMGA2 high mobility group AT-hook 2 -2.02813
SALL1 spalt-like transcription factor 1 -2.01702
DENND1B DENN/MADD domain containing 1B -2.0156
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.01449
HAT1 histone acetyltransferase 1 -2.01329
PCCB propionyl CoA carboxylase, beta polypeptide -2.00069