CRCGN009_HEPG2_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description auramine-o 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN009_HEPG2_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.68292
CDPF1 cysteine-rich, DPF motif domain containing 1 6.57901
MOK MOK protein kinase 3.82096
BACE2 beta-site APP-cleaving enzyme 2 3.74503
GPER1 G protein-coupled estrogen receptor 1 3.73349
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.44553
LCN2 lipocalin 2 3.30265
BLCAP bladder cancer associated protein 3.16459
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.0194
DIPK1A divergent protein kinase domain 1A 2.93393
MEST mesoderm specific transcript 2.8698
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.80523
INPP1 inositol polyphosphate-1-phosphatase 2.68761
LOC122526780 uncharacterized LOC122526780 2.67823
CNPY3 canopy FGF signaling regulator 3 2.66084
CCP110 centriolar coiled coil protein 110kDa 2.57336
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.53392
FPGS folylpolyglutamate synthase 2.49822
SFTPB surfactant protein B 2.46123
ATP11B ATPase, class VI, type 11B 2.43654
AXIN1 axin 1 2.42897
STIMATE STIM activating enhancer 2.40855
H2BC12 H2B clustered histone 12 2.35549
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.19274
ABHD4 abhydrolase domain containing 4 2.16404
CHN1 chimerin 1 2.16007
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.09848
TEX10 testis expressed 10 2.09701
TP53 tumor protein p53 2.04731

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.8363
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.77731
GNAS GNAS complex locus -4.65787
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.11566
OXA1L oxidase (cytochrome c) assembly 1-like -4.03684
PSRC1 proline/serine-rich coiled-coil 1 -3.89469
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.84671
CSK c-src tyrosine kinase -3.66309
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.39042
TRIB3 tribbles pseudokinase 3 -3.27406
NGRN neugrin, neurite outgrowth associated -3.25126
MELK maternal embryonic leucine zipper kinase -3.24275
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.16917
CRELD2 cysteine-rich with EGF-like domains 2 -3.13888
LDHD lactate dehydrogenase D -2.87398
ANO10 anoctamin 10 -2.82371
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.71353
PLK1 polo-like kinase 1 -2.50294
RSU1 Ras suppressor protein 1 -2.49821
TCTN1 tectonic family member 1 -2.48722
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.47947
DERA deoxyribose-phosphate aldolase (putative) -2.47629
ZMIZ1 zinc finger, MIZ-type containing 1 -2.40482
EIF5 eukaryotic translation initiation factor 5 -2.32528
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.20283
TLR4 toll-like receptor 4 -2.15465
STAMBP STAM binding protein -2.11225
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.07988
CDK1 cyclin-dependent kinase 1 -2.07788
FASTKD5 FAST kinase domains 5 -2.07257
VAT1 vesicle amine transport 1 -2.02947
NNT nicotinamide nucleotide transhydrogenase -2.02672