CRCGN009_HEPG2_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description auramine-o 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN009_HEPG2_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.57882
SNAP25 synaptosomal-associated protein, 25kDa 5.66207
LCN2 lipocalin 2 5.49818
SFTPB surfactant protein B 4.07133
CYCS cytochrome c, somatic 3.8349
GPER1 G protein-coupled estrogen receptor 1 3.79316
RPP38 ribonuclease P/MRP 38kDa subunit 3.47926
SQOR sulfide quinone oxidoreductase 3.30876
EAPP E2F-associated phosphoprotein 3.21987
CDC45 cell division cycle 45 3.00169
ZW10 zw10 kinetochore protein 2.84959
E2F2 E2F transcription factor 2 2.50646
CISD1 CDGSH iron sulfur domain 1 2.42836
STXBP2 syntaxin binding protein 2 2.26423
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.25386
H2BC12 H2B clustered histone 12 2.24309
SATB1 SATB homeobox 1 2.10154
TIAM1 T-cell lymphoma invasion and metastasis 1 2.09126
MAP7 microtubule-associated protein 7 2.07856
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.06243
TEX10 testis expressed 10 2.05719
KIAA0232 KIAA0232 2.05156
CCP110 centriolar coiled coil protein 110kDa 2.03082
HLA-DRA major histocompatibility complex, class II, DR alpha 2.02517
INPP1 inositol polyphosphate-1-phosphatase 2.01792

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.94072
CDC20 cell division cycle 20 -6.7242
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.0176
OXA1L oxidase (cytochrome c) assembly 1-like -3.97273
HYOU1 hypoxia up-regulated 1 -3.84229
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.77786
FGFR4 fibroblast growth factor receptor 4 -3.3908
LDHD lactate dehydrogenase D -2.83274
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.71441
VDAC1 voltage-dependent anion channel 1 -2.67829
MSRA methionine sulfoxide reductase A -2.63654
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.59513
CCNB2 cyclin B2 -2.51729
VAT1 vesicle amine transport 1 -2.5142
TRAP1 TNF receptor-associated protein 1 -2.48017
AADAC arylacetamide deacetylase -2.44093
NRIP1 nuclear receptor interacting protein 1 -2.43333
STMN1 stathmin 1 -2.35439
TCF21 transcription factor 21 -2.35232
RBM15B RNA binding motif protein 15B -2.27022
CCNB1 cyclin B1 -2.24454
STAT1 signal transducer and activator of transcription 1, 91kDa -2.22801
PPOX protoporphyrinogen oxidase -2.20997
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.11613
OTC ornithine carbamoyltransferase -2.09839
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -2.09575