CRCGN009_HEPG2_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monochloroacetic acid 1.21 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN009_HEPG2_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 5.61459
RPP38 ribonuclease P/MRP 38kDa subunit 5.32045
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.95168
MAP7 microtubule-associated protein 7 4.94582
STIMATE STIM activating enhancer 4.76794
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.33254
LOC122526780 uncharacterized LOC122526780 3.68418
CHEK2 checkpoint kinase 2 3.35037
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.31121
ADRB2 adrenoceptor beta 2, surface 3.12471
TIAM1 T-cell lymphoma invasion and metastasis 1 2.87977
KLHL21 kelch-like family member 21 2.79659
EVL Enah/Vasp-like 2.68312
JADE2 jade family PHD finger 2 2.6433
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.59821
LCN2 lipocalin 2 2.33129
STAP2 signal transducing adaptor family member 2 2.24521
HSPA1A heat shock 70kDa protein 1A 2.02029

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -8.83832
LDHD lactate dehydrogenase D -8.15433
VAT1 vesicle amine transport 1 -5.42645
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0071
TRIB3 tribbles pseudokinase 3 -4.99754
CCNB2 cyclin B2 -4.93618
TLR4 toll-like receptor 4 -4.51207
SNX11 sorting nexin 11 -3.99575
ZMIZ1 zinc finger, MIZ-type containing 1 -3.92997
FBXL12 F-box and leucine-rich repeat protein 12 -3.00645
MACF1 microtubule-actin crosslinking factor 1 -2.93576
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.93017
MAPK13 mitogen-activated protein kinase 13 -2.66014
RFC2 replication factor C (activator 1) 2, 40kDa -2.4536
CPNE3 copine III -2.44911
GNAS GNAS complex locus -2.43409
TWF2 twinfilin actin binding protein 2 -2.32874
BIRC2 baculoviral IAP repeat containing 2 -2.31308
CD58 CD58 molecule -2.20682
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.18259
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.09986
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.05464
ACBD4 acyl-CoA binding domain containing 4 -2.05192