CRCGN009_HEPG2_24H:O14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (1e)-2-methyl-1-({[(methylamino)carbonyl]oxy}imino)-2-(methylsulfanyl)propane 10.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN009_HEPG2_24H:O14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 6.30852
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.72027
TIAM1 T-cell lymphoma invasion and metastasis 1 4.40186
LPAR2 lysophosphatidic acid receptor 2 3.60126
LCN2 lipocalin 2 3.51691
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.46475
PRR15L proline rich 15-like 3.37805
CBR3 carbonyl reductase 3 3.29884
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.18529
SKIC2 SKI2 subunit of superkiller complex 3.03338
HOXA10 homeobox A10 3.01156
HLA-DMA major histocompatibility complex, class II, DM alpha 2.94654
TRAM2 translocation associated membrane protein 2 2.65927
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.63053
STXBP1 syntaxin binding protein 1 2.56686
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.40268
CHN1 chimerin 1 2.36477
MAP7 microtubule-associated protein 7 2.28465
STXBP2 syntaxin binding protein 2 2.2443
TEX10 testis expressed 10 2.1979
HEBP1 heme binding protein 1 2.16871
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.1535
GRB10 growth factor receptor-bound protein 10 2.05326

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.13763
LDHD lactate dehydrogenase D -6.23096
OXA1L oxidase (cytochrome c) assembly 1-like -4.92152
RPIA ribose 5-phosphate isomerase A -3.46801
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33952
RNF167 ring finger protein 167 -2.70149
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.57592
ZW10 zw10 kinetochore protein -2.49205
SNX11 sorting nexin 11 -2.44821
WASHC4 WASH complex subunit 4 -2.29338
NUDCD3 NudC domain containing 3 -2.23803
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.08922
DERA deoxyribose-phosphate aldolase (putative) -2.08374
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.03182