CRCGN009_HEPG2_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 10.42 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

304 genes differentially expressed following the CRCGN009_HEPG2_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
HSPA1A heat shock 70kDa protein 1A 8.46289
LCN2 lipocalin 2 7.14574
CBR1 carbonyl reductase 1 6.69119
ABHD4 abhydrolase domain containing 4 6.21041
CNPY3 canopy FGF signaling regulator 3 6.17759
RRAGA Ras-related GTP binding A 6.08717
SQOR sulfide quinone oxidoreductase 5.64136
INPP1 inositol polyphosphate-1-phosphatase 5.13414
LRP10 low density lipoprotein receptor-related protein 10 5.06458
TBPL1 TBP-like 1 4.97131
CGRRF1 cell growth regulator with ring finger domain 1 4.92322
NOTCH1 notch 1 4.71251
TOMM34 translocase of outer mitochondrial membrane 34 4.50222
GPER1 G protein-coupled estrogen receptor 1 4.47919
H2BC12 H2B clustered histone 12 4.47444
FOSL1 FOS-like antigen 1 4.15568
TUBB6 tubulin, beta 6 class V 4.14558
ATP11B ATPase, class VI, type 11B 4.11164
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.08919
SATB1 SATB homeobox 1 4.00637
KIFBP kinesin family binding protein 4.00494
EGR1 early growth response 1 3.98478
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.87828
IER3 immediate early response 3 3.8387
CIAO3 cytosolic iron-sulfur assembly component 3 3.79473
SQSTM1 sequestosome 1 3.68596
BAMBI BMP and activin membrane-bound inhibitor 3.67349
CXCR4 chemokine (C-X-C motif) receptor 4 3.51616
TIMP2 TIMP metallopeptidase inhibitor 2 3.51312
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.49148
SMAD3 SMAD family member 3 3.38124
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.37849
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.36484
KLHL21 kelch-like family member 21 3.33345
ARID5B AT rich interactive domain 5B (MRF1-like) 3.2964
TERF2IP telomeric repeat binding factor 2, interacting protein 3.25184
PEX11A peroxisomal biogenesis factor 11 alpha 3.2472
EPN2 epsin 2 3.24052
ALAS1 5'-aminolevulinate synthase 1 3.20944
ADRB2 adrenoceptor beta 2, surface 3.2024
HEBP1 heme binding protein 1 3.19961
ASCC3 activating signal cointegrator 1 complex subunit 3 3.1514
MEST mesoderm specific transcript 3.07588
TXNRD1 thioredoxin reductase 1 3.06454
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.00576
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.00568
CRIPT cysteine-rich PDZ-binding protein 2.97507
SLC35F2 solute carrier family 35, member F2 2.90379
PRR15L proline rich 15-like 2.90337
AMOTL2 angiomotin like 2 2.79948
RAB21 RAB21, member RAS oncogene family 2.73298
FRS2 fibroblast growth factor receptor substrate 2 2.72014
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.67743
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.63507
TMSB10 thymosin beta 10 2.63455
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.6159
BZW2 basic leucine zipper and W2 domains 2 2.60547
CTSD cathepsin D 2.59432
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.59016
CAB39 calcium binding protein 39 2.51357
RTL8A retrotransposon Gag like 8A 2.5117
SCAND1 SCAN domain containing 1 2.51145
RNF115 ring finger protein 115 2.48037
RBKS ribokinase 2.4509
EDN1 endothelin 1 2.43775
SNIP1 Smad nuclear interacting protein 1 2.43318
GADD45B growth arrest and DNA-damage-inducible, beta 2.41856
PRTN3 proteinase 3 2.41692
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.4059
ZFP36 ZFP36 ring finger protein 2.40522
SAR1B secretion associated, Ras related GTPase 1B 2.39666
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.38763
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.37158
MAP7D1 MAP7 domain containing 1 2.36396
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.36013
EFNB1 ephrin-B1 2.35716
FASTKD5 FAST kinase domains 5 2.35395
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.33108
ARID4B AT rich interactive domain 4B (RBP1-like) 2.32011
MAT2B methionine adenosyltransferase II, beta 2.318
GADD45A growth arrest and DNA-damage-inducible, alpha 2.31786
MVP major vault protein 2.3131
LYRM1 LYR motif containing 1 2.31211
SMNDC1 survival motor neuron domain containing 1 2.31143
MAP1S microtubule-associated protein 1S 2.29095
TEX10 testis expressed 10 2.28906
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.28699
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.26605
IL4R interleukin 4 receptor 2.26527
UTP11 UTP11 small subunit processome component 2.25979
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.25066
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.24067
BAG3 BCL2-associated athanogene 3 2.23515
CIAO2B cytosolic iron-sulfur assembly component 2B 2.22912
TSPAN3 tetraspanin 3 2.22304
ELANE elastase, neutrophil expressed 2.21735
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.21288
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.20287
FEZF2 FEZ family zinc finger 2 2.20139
DCTN3 dynactin 3 (p22) 2.19389
GPC1 glypican 1 2.18951
MRPS10 mitochondrial ribosomal protein S10 2.18076
ZYX zyxin 2.17149
SLC75A1 solute carrier family 75 member 1 2.16932
SNX7 sorting nexin 7 2.16673
H2AC6 H2A clustered histone 6 2.16244
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.15461
RIN2 Ras and Rab interactor 2 2.14895
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.14699
PHACTR1 phosphatase and actin regulator 1 2.14022
MYOF myoferlin 2.13344
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.13119
RGPD1 RANBP2-like and GRIP domain containing 1 2.1308
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.13007
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.11744
UNC13A unc-13 homolog A (C. elegans) 2.10945
EPHA2 EPH receptor A2 2.10284
RAI14 retinoic acid induced 14 2.09792
TERF2 telomeric repeat binding factor 2 2.09524
RUSC2 RUN and SH3 domain containing 2 2.09485
CDIP1 cell death-inducing p53 target 1 2.0947
BET1 Bet1 golgi vesicular membrane trafficking protein 2.09447
LOC122526780 uncharacterized LOC122526780 2.09267
MON1B MON1 secretory trafficking family member B 2.09031
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.075
APMAP adipocyte plasma membrane associated protein 2.075
HSPA1B heat shock 70kDa protein 1B 2.06514
SOCS2 suppressor of cytokine signaling 2 2.06299
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.05978
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.05792
TRIB1 tribbles pseudokinase 1 2.05651
EHD2 EH-domain containing 2 2.05466
UBE2H ubiquitin-conjugating enzyme E2H 2.0531
TBP TATA box binding protein 2.05099
GOLT1B golgi transport 1B 2.04623
NCS1 neuronal calcium sensor 1 2.0428
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.04172
ATP8B4 ATPase, class I, type 8B, member 4 2.04139
KDM5A lysine (K)-specific demethylase 5A 2.03783
ZNF358 zinc finger protein 358 2.0378
AZU1 azurocidin 1 2.03114
MRPS15 mitochondrial ribosomal protein S15 2.02932
EXOC5 exocyst complex component 5 2.02904
MCFD2 multiple coagulation factor deficiency 2 2.0261
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.01397
JUN jun proto-oncogene 2.00731
LACTB2 lactamase, beta 2 2.0006

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -9.69985
ZNF586 zinc finger protein 586 -8.87764
TCTN1 tectonic family member 1 -7.82156
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -7.2027
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.15849
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.81093
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.62782
LAP3 leucine aminopeptidase 3 -6.53422
FGFR4 fibroblast growth factor receptor 4 -6.04499
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.7721
PSRC1 proline/serine-rich coiled-coil 1 -5.2874
PROS1 protein S (alpha) -5.1136
ERBB2 erb-b2 receptor tyrosine kinase 2 -4.97786
PYCR1 pyrroline-5-carboxylate reductase 1 -4.97298
CCNB1 cyclin B1 -4.95142
LOC124907782 dual specificity protein phosphatase 22 -4.9506
ZW10 zw10 kinetochore protein -4.94573
KLHDC2 kelch domain containing 2 -4.59439
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.43184
C5 complement component 5 -4.34825
AKAP8 A kinase (PRKA) anchor protein 8 -4.33024
CSK c-src tyrosine kinase -4.31351
RFC2 replication factor C (activator 1) 2, 40kDa -4.28818
PGM1 phosphoglucomutase 1 -4.12035
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -4.02446
FBXL12 F-box and leucine-rich repeat protein 12 -3.94251
PHGDH phosphoglycerate dehydrogenase -3.92206
ENOPH1 enolase-phosphatase 1 -3.89673
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.7747
TOP2A topoisomerase (DNA) II alpha 170kDa -3.76976
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.68128
TLR4 toll-like receptor 4 -3.58806
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.47208
ACAA1 acetyl-CoA acyltransferase 1 -3.39147
MLEC malectin -3.35744
CCNA2 cyclin A2 -3.35021
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.34549
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.32854
CCDC86 coiled-coil domain containing 86 -3.27949
HYOU1 hypoxia up-regulated 1 -3.26219
AARS1 alanyl-tRNA synthetase 1 -3.2498
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.20573
NT5DC2 5'-nucleotidase domain containing 2 -3.18895
ISOC1 isochorismatase domain containing 1 -3.10173
LBR lamin B receptor -3.04796
GNAS GNAS complex locus -3.04473
INTS3 integrator complex subunit 3 -3.02934
ZNF318 zinc finger protein 318 -3.01445
AURKB aurora kinase B -2.99749
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.9372
TCERG1 transcription elongation regulator 1 -2.88745
PCCB propionyl CoA carboxylase, beta polypeptide -2.88272
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.87959
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.86868
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.84056
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.82592
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.80722
CHMP4B charged multivesicular body protein 4B -2.80537
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.7578
RGS2 regulator of G-protein signaling 2 -2.73717
GAA glucosidase, alpha; acid -2.73237
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.73236
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.71576
CPZ carboxypeptidase Z -2.70774
TLCD3A TLC domain containing 3A -2.70525
ECH1 enoyl CoA hydratase 1, peroxisomal -2.70367
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.68629
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.68306
C2CD5 C2 calcium-dependent domain containing 5 -2.6735
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.66552
ZNF443 zinc finger protein 443 -2.64686
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.62878
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.62318
C1R complement component 1, r subcomponent -2.61411
MTA1 metastasis associated 1 -2.58183
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.57258
RBM6 RNA binding motif protein 6 -2.56804
AMBP alpha-1-microglobulin/bikunin precursor -2.56049
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.55741
ZNF266 zinc finger protein 266 -2.55582
ZNF587B zinc finger protein 587B -2.54413
ASGR1 asialoglycoprotein receptor 1 -2.53885
SOAT2 sterol O-acyltransferase 2 -2.53392
GCH1 GTP cyclohydrolase 1 -2.49988
GALE UDP-galactose-4-epimerase -2.47569
ZNF134 zinc finger protein 134 -2.46472
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.46123
PEG3 paternally expressed 3 -2.46106
LIME1 Lck interacting transmembrane adaptor 1 -2.45504
ANOS1 anosmin 1 -2.44796
HADH hydroxyacyl-CoA dehydrogenase -2.44466
CDK4 cyclin-dependent kinase 4 -2.43429
NCK2 NCK adaptor protein 2 -2.43177
ZNF419 zinc finger protein 419 -2.42476
CDK1 cyclin-dependent kinase 1 -2.38478
RSU1 Ras suppressor protein 1 -2.34835
PXMP2 peroxisomal membrane protein 2, 22kDa -2.33505
MARS1 methionyl-tRNA synthetase 1 -2.32684
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.30573
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.29296
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.29067
DCP2 decapping mRNA 2 -2.28444
COPZ1 coatomer protein complex, subunit zeta 1 -2.28355
ZBED1 zinc finger, BED-type containing 1 -2.27747
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.2721
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.25174
STK25 serine/threonine kinase 25 -2.24101
PTK6 protein tyrosine kinase 6 -2.22994
TAGLN transgelin -2.22826
PLK1 polo-like kinase 1 -2.2265
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.22332
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.22262
LIN28A lin-28 homolog A (C. elegans) -2.21906
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.21055
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.20534
BIRC5 baculoviral IAP repeat containing 5 -2.19468
TRAP1 TNF receptor-associated protein 1 -2.18763
RAB26 RAB26, member RAS oncogene family -2.17765
ALDOC aldolase C, fructose-bisphosphate -2.17724
HMOX1 heme oxygenase 1 -2.16973
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -2.16932
CCNB2 cyclin B2 -2.1661
GYG2 glycogenin 2 -2.16341
SIRAL2 SIR2 antiphage like 2 -2.15537
MPHOSPH9 M-phase phosphoprotein 9 -2.15346
AURKC aurora kinase C -2.15137
TATDN2 TatD DNase domain containing 2 -2.14109
APOH apolipoprotein H (beta-2-glycoprotein I) -2.13468
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.13457
MIS18BP1 MIS18 binding protein 1 -2.13157
STMN1 stathmin 1 -2.12191
CD3D CD3d molecule, delta (CD3-TCR complex) -2.10749
TEAD4 TEA domain family member 4 -2.10743
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -2.10704
PYGL phosphorylase, glycogen, liver -2.10486
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.1037
CALB1 calbindin 1, 28kDa -2.0897
FGFR3 fibroblast growth factor receptor 3 -2.08268
GFUS GDP-L-fucose synthase -2.07359
NOD2 nucleotide-binding oligomerization domain containing 2 -2.06981
FTCD formimidoyltransferase cyclodeaminase -2.06032
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.0593
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.05255
LCK LCK proto-oncogene, Src family tyrosine kinase -2.05017
RHOH ras homolog family member H -2.04245
TMEM97 transmembrane protein 97 -2.03907
NCAPD2 non-SMC condensin I complex, subunit D2 -2.03871
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.03603
KCTD7 potassium channel tetramerization domain containing 7 -2.03504
NNT nicotinamide nucleotide transhydrogenase -2.0288
PLBD1 phospholipase B domain containing 1 -2.02872
HAPSTR1 HUWE1 associated protein modifying stress responses -2.02401
PBX3 pre-B-cell leukemia homeobox 3 -2.02251
CASC3 cancer susceptibility candidate 3 -2.02021
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.00891
VAV3 vav 3 guanine nucleotide exchange factor -2.00249