| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 5.21 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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102 genes differentially expressed following the CRCGN009_HEPG2_24H:O21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| CNPY3 | canopy FGF signaling regulator 3 | 7.38018 |
| CHMP6 | charged multivesicular body protein 6 | 6.92912 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 6.26227 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 5.04392 |
| ZNF589 | zinc finger protein 589 | 4.90646 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.90415 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 4.51136 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.77881 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.76799 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.68558 |
| IER3 | immediate early response 3 | 3.47177 |
| SQOR | sulfide quinone oxidoreductase | 3.23331 |
| CRTAP | cartilage associated protein | 3.18926 |
| CCP110 | centriolar coiled coil protein 110kDa | 3.1191 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.06085 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.03736 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.93838 |
| CYCS | cytochrome c, somatic | 2.91642 |
| UBQLN2 | ubiquilin 2 | 2.79516 |
| FPGS | folylpolyglutamate synthase | 2.74651 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.69827 |
| GATA2 | GATA binding protein 2 | 2.6759 |
| ABHD6 | abhydrolase domain containing 6 | 2.65734 |
| CBR1 | carbonyl reductase 1 | 2.63097 |
| ILKAP | integrin-linked kinase-associated serine/threonine phosphatase | 2.60783 |
| TUBB6 | tubulin, beta 6 class V | 2.60083 |
| SFTPB | surfactant protein B | 2.53028 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.50052 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.37715 |
| SMAD3 | SMAD family member 3 | 2.32411 |
| FOSL1 | FOS-like antigen 1 | 2.27254 |
| ZNF536 | zinc finger protein 536 | 2.21343 |
| SLC35F2 | solute carrier family 35, member F2 | 2.17229 |
| MAP7 | microtubule-associated protein 7 | 2.16174 |
| EGR1 | early growth response 1 | 2.15285 |
| TG | thyroglobulin | 2.13951 |
| GLRX | glutaredoxin (thioltransferase) | 2.12069 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.11244 |
| ERCC1 | excision repair cross-complementation group 1 | 2.09144 |
| MRPS10 | mitochondrial ribosomal protein S10 | 2.08709 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 2.06595 |
| CISD1 | CDGSH iron sulfur domain 1 | 2.04741 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 2.01997 |
| IL4R | interleukin 4 receptor | 2.01466 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.00706 |
| TEX10 | testis expressed 10 | 2.00269 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -7.58263 |
| FGFR4 | fibroblast growth factor receptor 4 | -7.55763 |
| TCTN1 | tectonic family member 1 | -6.64086 |
| ISOC1 | isochorismatase domain containing 1 | -5.51401 |
| UBE3C | ubiquitin protein ligase E3C | -5.37872 |
| ZW10 | zw10 kinetochore protein | -5.27761 |
| COG2 | component of oligomeric golgi complex 2 | -4.04464 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -3.71226 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.45951 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -3.30866 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -3.23637 |
| PGM1 | phosphoglucomutase 1 | -3.0978 |
| ZNF586 | zinc finger protein 586 | -3.07072 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.06357 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.99154 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.92213 |
| VDAC1 | voltage-dependent anion channel 1 | -2.89378 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.81061 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.75133 |
| ICAM3 | intercellular adhesion molecule 3 | -2.72295 |
| VAT1 | vesicle amine transport 1 | -2.70998 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.70273 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.62336 |
| PGRMC1 | progesterone receptor membrane component 1 | -2.61234 |
| LDHD | lactate dehydrogenase D | -2.60701 |
| AURKB | aurora kinase B | -2.56314 |
| MYL9 | myosin, light chain 9, regulatory | -2.47144 |
| SOAT2 | sterol O-acyltransferase 2 | -2.44099 |
| AARS1 | alanyl-tRNA synthetase 1 | -2.42894 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.37557 |
| PHGDH | phosphoglycerate dehydrogenase | -2.34779 |
| HYOU1 | hypoxia up-regulated 1 | -2.32574 |
| RNF130 | ring finger protein 130 | -2.32448 |
| PLK1 | polo-like kinase 1 | -2.3052 |
| PROS1 | protein S (alpha) | -2.27824 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | -2.27096 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.27074 |
| LIPC | lipase, hepatic | -2.24493 |
| RBM15 | RNA binding motif protein 15 | -2.24319 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -2.21868 |
| HMG20B | high mobility group 20B | -2.19492 |
| SLC17A2 | solute carrier family 17, member 2 | -2.15885 |
| PCNA | proliferating cell nuclear antigen | -2.15485 |
| THEM6 | thioesterase superfamily member 6 | -2.15041 |
| TLR4 | toll-like receptor 4 | -2.14843 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.13133 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.13089 |
| NFE2 | nuclear factor, erythroid 2 | -2.0956 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.07856 |
| UPK1A | uroplakin 1A | -2.06449 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.04649 |
| SPON1 | spondin 1, extracellular matrix protein | -2.02681 |
| HMOX1 | heme oxygenase 1 | -2.02438 |
| HOXA5 | homeobox A5 | -2.01267 |
| CA5A | carbonic anhydrase VA, mitochondrial | -2.00458 |
