CRCGN009_HEPG2_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN009_HEPG2_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 6.61203
RXYLT1 ribitol xylosyltransferase 1 4.9947
CHN1 chimerin 1 4.70701
PNKP polynucleotide kinase 3'-phosphatase 4.47612
TIAM1 T-cell lymphoma invasion and metastasis 1 4.08403
E2F2 E2F transcription factor 2 3.97588
MAMLD1 mastermind-like domain containing 1 3.91335
CYCS cytochrome c, somatic 3.86739
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.71187
ANO1 anoctamin 1, calcium activated chloride channel 3.5608
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.516
SNAP25 synaptosomal-associated protein, 25kDa 3.5136
BACE2 beta-site APP-cleaving enzyme 2 3.47122
ATP11B ATPase, class VI, type 11B 3.44248
CBR3 carbonyl reductase 3 3.39127
HOXA10 homeobox A10 3.38368
MAP7 microtubule-associated protein 7 3.38157
PFKL phosphofructokinase, liver 3.18692
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.04253
HSPA1A heat shock 70kDa protein 1A 2.91199
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.90202
STK10 serine/threonine kinase 10 2.88375
IQGAP1 IQ motif containing GTPase activating protein 1 2.85223
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.80372
NOSIP nitric oxide synthase interacting protein 2.68358
ABHD6 abhydrolase domain containing 6 2.66093
GSTZ1 glutathione S-transferase zeta 1 2.65423
MRPL12 mitochondrial ribosomal protein L12 2.60016
LOC122526780 uncharacterized LOC122526780 2.55014
GATA3 GATA binding protein 3 2.48165
JADE2 jade family PHD finger 2 2.46995
CXCL2 chemokine (C-X-C motif) ligand 2 2.43997
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.41265
EPHA3 EPH receptor A3 2.40539
HLA-DRA major histocompatibility complex, class II, DR alpha 2.30801
SIRPG signal-regulatory protein gamma 2.24888
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.20068
CCND1 cyclin D1 2.18163
EVL Enah/Vasp-like 2.17539
PRKCH protein kinase C, eta 2.15663
YJU2B YJU2 splicing factor homolog B 2.09637
BCL7B B-cell CLL/lymphoma 7B 2.09422
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.04526
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 2.02658
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.02038

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.86629
CCNB2 cyclin B2 -5.69112
HAT1 histone acetyltransferase 1 -5.08356
TLCD3A TLC domain containing 3A -4.80362
PEG10 paternally expressed 10 -4.37189
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.90631
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.86157
RAI14 retinoic acid induced 14 -3.8155
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.62296
TLR4 toll-like receptor 4 -3.31161
EGF epidermal growth factor -3.16437
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.12098
CDC20 cell division cycle 20 -3.04758
DNM1L dynamin 1-like -3.0418
NT5DC2 5'-nucleotidase domain containing 2 -3.03067
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.99979
HYOU1 hypoxia up-regulated 1 -2.87537
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.74764
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.70669
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.66752
NGRN neugrin, neurite outgrowth associated -2.56618
TCEAL4 transcription elongation factor A (SII)-like 4 -2.55249
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.50441
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.41185
KIF13A kinesin family member 13A -2.29618
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.20497
ZNF586 zinc finger protein 586 -2.11255
SESN1 sestrin 1 -2.10789
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.09381
ZFP36 ZFP36 ring finger protein -2.08575
UBQLN2 ubiquilin 2 -2.08227
SCTR secretin receptor -2.02202
LDHD lactate dehydrogenase D -2.00812
PCNA proliferating cell nuclear antigen -2.00162