CRCGN009_HEPG2_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

184 genes differentially expressed following the CRCGN009_HEPG2_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GFOD1 glucose-fructose oxidoreductase domain containing 1 6.32267
CBR3 carbonyl reductase 3 4.96832
MAP7 microtubule-associated protein 7 4.78531
MEST mesoderm specific transcript 4.22891
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 4.21494
HDGFL3 HDGF like 3 4.11945
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.05374
CCDC86 coiled-coil domain containing 86 3.8443
PLS1 plastin 1 3.82944
NNT nicotinamide nucleotide transhydrogenase 3.78104
CEMIP2 cell migration inducing hyaluronidase 2 3.7788
CARMIL1 capping protein regulator and myosin 1 linker 1 3.65349
LPAR2 lysophosphatidic acid receptor 2 3.6473
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.64521
NUP133 nucleoporin 133kDa 3.56897
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.54456
NT5DC2 5'-nucleotidase domain containing 2 3.5192
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.253
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.20068
CASC3 cancer susceptibility candidate 3 3.19277
UBE3C ubiquitin protein ligase E3C 3.10667
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.02517
TRAP1 TNF receptor-associated protein 1 2.98928
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.87816
COG2 component of oligomeric golgi complex 2 2.76281
AMDHD2 amidohydrolase domain containing 2 2.74409
CBR1 carbonyl reductase 1 2.7422
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.70907
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.68751
HOOK2 hook microtubule-tethering protein 2 2.68559
GPATCH8 G patch domain containing 8 2.67709
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.67292
ABHD4 abhydrolase domain containing 4 2.64053
GALE UDP-galactose-4-epimerase 2.61051
CIAO3 cytosolic iron-sulfur assembly component 3 2.58788
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.56775
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.56178
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.51828
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.49826
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.48689
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.42702
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.40585
MELK maternal embryonic leucine zipper kinase 2.38909
PYCR1 pyrroline-5-carboxylate reductase 1 2.36608
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.36146
MICALL1 MICAL-like 1 2.36063
CTNNBIP1 catenin, beta interacting protein 1 2.35459
DUSP14 dual specificity phosphatase 14 2.31675
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.31315
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.30848
PNKP polynucleotide kinase 3'-phosphatase 2.30609
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.26824
AARS1 alanyl-tRNA synthetase 1 2.2239
ZNF750 zinc finger protein 750 2.21523
CREB1 cAMP responsive element binding protein 1 2.20892
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.19432
NIT1 nitrilase 1 2.18746
ANO1 anoctamin 1, calcium activated chloride channel 2.18515
ZNF274 zinc finger protein 274 2.18035
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.17517
WDR7 WD repeat domain 7 2.16694
NISCH nischarin 2.16657
PRKCD protein kinase C, delta 2.1631
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.15272
PRSS8 protease, serine, 8 2.14029
CD151 CD151 molecule (Raph blood group) 2.13757
ALAS1 5'-aminolevulinate synthase 1 2.13099
CDK6 cyclin-dependent kinase 6 2.13062
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.12817
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.12731
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.12704
STX1A syntaxin 1A (brain) 2.12618
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.12451
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.12285
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.11717
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.10957
CCP110 centriolar coiled coil protein 110kDa 2.10237
MBNL2 muscleblind-like splicing regulator 2 2.09873
PRUNE1 prune exopolyphosphatase 1 2.08258
BLCAP bladder cancer associated protein 2.07619
TYW2 tRNA wybutosine-synthesizing protein 2 2.05461
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.05121
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.04547
FIG4 FIG4 phosphoinositide 5-phosphatase 2.03812
ZNF571 zinc finger protein 571 2.03611
SCARB1 scavenger receptor class B, member 1 2.03541
E2F2 E2F transcription factor 2 2.03245
EGF epidermal growth factor 2.0259
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.01479
RALGDS ral guanine nucleotide dissociation stimulator 2.01391
HP1BP3 heterochromatin protein 1, binding protein 3 2.01161

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.82799
SCAND1 SCAN domain containing 1 -7.50251
SLC35F2 solute carrier family 35, member F2 -7.49946
ZW10 zw10 kinetochore protein -7.37506
CRYZ crystallin, zeta (quinone reductase) -4.77624
CAB39 calcium binding protein 39 -4.75134
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.74291
ADI1 acireductone dioxygenase 1 -4.5625
MTFR1 mitochondrial fission regulator 1 -4.49674
TM9SF3 transmembrane 9 superfamily member 3 -4.43109
OXA1L oxidase (cytochrome c) assembly 1-like -4.39725
TCTN1 tectonic family member 1 -4.28972
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.2712
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.16872
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.14112
CDC20 cell division cycle 20 -4.10124
NGRN neugrin, neurite outgrowth associated -4.09396
CCNH cyclin H -3.79358
ENOPH1 enolase-phosphatase 1 -3.61604
ELAC2 elaC ribonuclease Z 2 -3.59072
NUP93 nucleoporin 93kDa -3.38909
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.38665
RNF167 ring finger protein 167 -3.3793
LOC124907782 dual specificity protein phosphatase 22 -3.3293
HAT1 histone acetyltransferase 1 -3.31121
HYOU1 hypoxia up-regulated 1 -3.30337
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.20972
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.18117
PLK1 polo-like kinase 1 -3.16643
DYNLT3 dynein, light chain, Tctex-type 3 -3.14589
EAPP E2F-associated phosphoprotein -3.11494
TM9SF2 transmembrane 9 superfamily member 2 -3.06693
TBPL1 TBP-like 1 -3.04577
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.95422
CCNB2 cyclin B2 -2.95353
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.93551
THAP11 THAP domain containing 11 -2.9085
USP22 ubiquitin specific peptidase 22 -2.8881
DSG2 desmoglein 2 -2.88271
TOMM34 translocase of outer mitochondrial membrane 34 -2.86115
CHMP4B charged multivesicular body protein 4B -2.83393
SMNDC1 survival motor neuron domain containing 1 -2.82601
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.82493
SQOR sulfide quinone oxidoreductase -2.79164
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.77598
GTPBP8 GTP-binding protein 8 (putative) -2.76587
DDIT4 DNA-damage-inducible transcript 4 -2.71477
PRCP prolylcarboxypeptidase (angiotensinase C) -2.69028
CSK c-src tyrosine kinase -2.6684
ELOVL6 ELOVL fatty acid elongase 6 -2.65529
EBNA1BP2 EBNA1 binding protein 2 -2.56763
VAT1 vesicle amine transport 1 -2.51898
HSPA1A heat shock 70kDa protein 1A -2.49974
ANXA7 annexin A7 -2.48104
SARAF store-operated calcium entry-associated regulatory factor -2.47715
IGFLR1 IGF-like family receptor 1 -2.45
CDK4 cyclin-dependent kinase 4 -2.42222
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.41216
ZNF586 zinc finger protein 586 -2.39353
RNASE7 ribonuclease, RNase A family, 7 -2.38213
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.35628
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.33563
MAPK12 mitogen-activated protein kinase 12 -2.3107
GOLT1B golgi transport 1B -2.2921
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.28095
KDM3A lysine (K)-specific demethylase 3A -2.25743
DCK deoxycytidine kinase -2.25414
RPN1 ribophorin I -2.24457
ISOC1 isochorismatase domain containing 1 -2.24375
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.23265
UBQLN2 ubiquilin 2 -2.22243
SOAT2 sterol O-acyltransferase 2 -2.20996
BLMH bleomycin hydrolase -2.19337
FBXL12 F-box and leucine-rich repeat protein 12 -2.17956
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.17629
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.16092
EVI2A ecotropic viral integration site 2A -2.13564
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.12673
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.09805
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.09729
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.09706
ARID5B AT rich interactive domain 5B (MRF1-like) -2.08226
CGRRF1 cell growth regulator with ring finger domain 1 -2.07417
MYL9 myosin, light chain 9, regulatory -2.0581
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.04132
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.03454
ZZZ3 zinc finger, ZZ-type containing 3 -2.02186
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.02148
ACAA1 acetyl-CoA acyltransferase 1 -2.02057
CPNE1 copine I -2.01462
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.01121
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.0104
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.00111