CRCGN009_HEPG2_24H:P04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 4.98 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN009_HEPG2_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.31393
PPARG peroxisome proliferator-activated receptor gamma 7.21912
AMDHD2 amidohydrolase domain containing 2 7.03212
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.70337
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.39624
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.22549
CCL2 chemokine (C-C motif) ligand 2 4.54157
RXYLT1 ribitol xylosyltransferase 1 4.37022
PNKP polynucleotide kinase 3'-phosphatase 4.05032
MCOLN1 mucolipin 1 3.90879
ANO1 anoctamin 1, calcium activated chloride channel 3.89011
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.79068
CARMIL1 capping protein regulator and myosin 1 linker 1 3.76538
NFIL3 nuclear factor, interleukin 3 regulated 3.62598
GARRE1 granule associated Rac and RHOG effector 1 3.47857
E2F2 E2F transcription factor 2 3.45276
UBQLN2 ubiquilin 2 3.45162
INTS3 integrator complex subunit 3 3.41786
LPAR2 lysophosphatidic acid receptor 2 3.37604
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.26904
MAP7 microtubule-associated protein 7 3.17479
ADRB2 adrenoceptor beta 2, surface 3.10327
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.06828
CXCL2 chemokine (C-X-C motif) ligand 2 2.95597
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.91233
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.80901
DYNLT3 dynein, light chain, Tctex-type 3 2.7502
HDGFL3 HDGF like 3 2.7288
EPHA3 EPH receptor A3 2.72652
RPP38 ribonuclease P/MRP 38kDa subunit 2.56459
HSPA1A heat shock 70kDa protein 1A 2.51284
VAV3 vav 3 guanine nucleotide exchange factor 2.50118
GATA3 GATA binding protein 3 2.49272
MSRA methionine sulfoxide reductase A 2.42314
PLPP3 phospholipid phosphatase 3 2.3728
GPER1 G protein-coupled estrogen receptor 1 2.35485
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.339
CHMP6 charged multivesicular body protein 6 2.29183
CNPY3 canopy FGF signaling regulator 3 2.28629
EVL Enah/Vasp-like 2.25571
TNIP1 TNFAIP3 interacting protein 1 2.25254
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.2188
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.21812
MYO5C myosin VC 2.20652
FZD7 frizzled class receptor 7 2.16029
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.15252
ADGRE5 adhesion G protein-coupled receptor E5 2.11512
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.09219
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.07356
TNNT3 troponin T type 3 (skeletal, fast) 2.02525
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.01202
RRAGA Ras-related GTP binding A 2.00053

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.92046
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.48861
RFC2 replication factor C (activator 1) 2, 40kDa -5.23447
PECR peroxisomal trans-2-enoyl-CoA reductase -4.88287
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.89215
NUP93 nucleoporin 93kDa -3.8904
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.7878
MRPS2 mitochondrial ribosomal protein S2 -3.71699
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.50564
UGDH UDP-glucose 6-dehydrogenase -3.48157
PSRC1 proline/serine-rich coiled-coil 1 -3.46537
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.34056
ADI1 acireductone dioxygenase 1 -3.32733
RPIA ribose 5-phosphate isomerase A -3.1869
DERA deoxyribose-phosphate aldolase (putative) -3.10353
TLR4 toll-like receptor 4 -2.97539
TOMM34 translocase of outer mitochondrial membrane 34 -2.95021
TCEAL4 transcription elongation factor A (SII)-like 4 -2.84775
CCNB2 cyclin B2 -2.83913
GOLT1B golgi transport 1B -2.77564
ZW10 zw10 kinetochore protein -2.67555
VAT1 vesicle amine transport 1 -2.67093
TCERG1 transcription elongation regulator 1 -2.66273
CRELD2 cysteine-rich with EGF-like domains 2 -2.64777
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.6269
PCNA proliferating cell nuclear antigen -2.60799
LDHD lactate dehydrogenase D -2.58775
ZNF274 zinc finger protein 274 -2.51608
CCNB1 cyclin B1 -2.51447
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.45462
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.44324
DDIT4 DNA-damage-inducible transcript 4 -2.32664
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.16863
PROS1 protein S (alpha) -2.15951
GNAS GNAS complex locus -2.12876
SNX11 sorting nexin 11 -2.08893
HEATR1 HEAT repeat containing 1 -2.03375
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.02943
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.01759