CRCGN009_HEPG2_24H:P06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN009_HEPG2_24H:P06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 6.83068
MYLK myosin light chain kinase 4.85225
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.78513
CYCS cytochrome c, somatic 3.4832
GPER1 G protein-coupled estrogen receptor 1 3.28752
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.84992
STK10 serine/threonine kinase 10 2.62967
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.57124
TENT4A terminal nucleotidyltransferase 4A 2.52084
CHMP6 charged multivesicular body protein 6 2.35932
NPDC1 neural proliferation, differentiation and control, 1 2.18631
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.08478
NUP133 nucleoporin 133kDa 2.05695
CEMIP2 cell migration inducing hyaluronidase 2 2.01297

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -4.93778
LDHD lactate dehydrogenase D -4.42291
FGFR4 fibroblast growth factor receptor 4 -4.10375
TLCD3A TLC domain containing 3A -4.08037
PRPF4 pre-mRNA processing factor 4 -3.54909
RPIA ribose 5-phosphate isomerase A -3.17308
ZDHHC6 zinc finger, DHHC-type containing 6 -3.15017
NGRN neugrin, neurite outgrowth associated -3.05515
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.9933
ICAM3 intercellular adhesion molecule 3 -2.76189
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.70253
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.67409
SLC35F2 solute carrier family 35, member F2 -2.62238
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.60278
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.57111
KDM3A lysine (K)-specific demethylase 3A -2.55205
NT5DC2 5'-nucleotidase domain containing 2 -2.49982
HEATR1 HEAT repeat containing 1 -2.44186
CDC20 cell division cycle 20 -2.43085
TCTN1 tectonic family member 1 -2.08521
GNAS GNAS complex locus -2.04288
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.02085