CRCGN009_HEPG2_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo-p-dioxin 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 5.42566
PLS1 plastin 1 4.83068
LCN2 lipocalin 2 4.76183
CHMP6 charged multivesicular body protein 6 4.64745
UBQLN2 ubiquilin 2 4.52599
NOTCH1 notch 1 3.30025
PPARG peroxisome proliferator-activated receptor gamma 3.0424
UBE2A ubiquitin-conjugating enzyme E2A 2.78564
CNPY3 canopy FGF signaling regulator 3 2.72566
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.70977
MEST mesoderm specific transcript 2.70532
NOSIP nitric oxide synthase interacting protein 2.54101
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.50604
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.48323
LPAR2 lysophosphatidic acid receptor 2 2.42578
CHN1 chimerin 1 2.3646
TBC1D31 TBC1 domain family, member 31 2.21259
OXCT1 3-oxoacid CoA transferase 1 2.19512
TXNRD1 thioredoxin reductase 1 2.19317
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.07001

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.78447
TUBB6 tubulin, beta 6 class V -5.3809
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.98196
ZNF586 zinc finger protein 586 -4.936
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.69443
LDHD lactate dehydrogenase D -4.65278
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.5232
WASHC4 WASH complex subunit 4 -4.32074
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.19923
PECR peroxisomal trans-2-enoyl-CoA reductase -3.96087
CAB39 calcium binding protein 39 -3.94748
OXA1L oxidase (cytochrome c) assembly 1-like -3.87185
UGDH UDP-glucose 6-dehydrogenase -3.63966
CSK c-src tyrosine kinase -3.45211
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.9639
ZW10 zw10 kinetochore protein -2.82413
PCNA proliferating cell nuclear antigen -2.73381
CCNB2 cyclin B2 -2.57531
DDIT4 DNA-damage-inducible transcript 4 -2.30685
TLCD3A TLC domain containing 3A -2.26838
FHL2 four and a half LIM domains 2 -2.25627
TLR4 toll-like receptor 4 -2.05708