CRCGN009_HEPG2_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo-p-dioxin 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN009_HEPG2_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 9.50331
E2F2 E2F transcription factor 2 5.34023
MYLK myosin light chain kinase 5.05533
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.92891
RPP38 ribonuclease P/MRP 38kDa subunit 4.64822
CXCL2 chemokine (C-X-C motif) ligand 2 4.53629
CYCS cytochrome c, somatic 4.52887
ADRB2 adrenoceptor beta 2, surface 4.28433
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.22313
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.07836
ABHD6 abhydrolase domain containing 6 3.94477
CBR3 carbonyl reductase 3 3.90315
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.31239
SATB1 SATB homeobox 1 2.98663
TXNL4B thioredoxin-like 4B 2.89209
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.66774
UFM1 ubiquitin-fold modifier 1 2.57738
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.44518
GPATCH8 G patch domain containing 8 2.3666
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.34809
CHEK2 checkpoint kinase 2 2.24361
LCN2 lipocalin 2 2.13247
RBBP7 retinoblastoma binding protein 7 2.11936
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.11484
GRWD1 glutamate-rich WD repeat containing 1 2.11475
SLC25A46 solute carrier family 25, member 46 2.08712
MEST mesoderm specific transcript 2.08125
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.06781
HAUS3 HAUS augmin-like complex, subunit 3 2.06137
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.03715
DNAAF5 dynein, axonemal, assembly factor 5 2.0361
HOOK2 hook microtubule-tethering protein 2 2.01579

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.68956
ZNF586 zinc finger protein 586 -4.98873
UBE3C ubiquitin protein ligase E3C -4.69691
DNM1L dynamin 1-like -4.40705
NGRN neugrin, neurite outgrowth associated -4.11646
TSPAN4 tetraspanin 4 -3.88467
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.35771
HMG20B high mobility group 20B -3.21404
CD58 CD58 molecule -3.05515
CCNB2 cyclin B2 -3.05314
MTFR1 mitochondrial fission regulator 1 -2.89015
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.6666
EIF5 eukaryotic translation initiation factor 5 -2.59326
TCEAL4 transcription elongation factor A (SII)-like 4 -2.53627
ACAA1 acetyl-CoA acyltransferase 1 -2.29552
CD34 CD34 molecule -2.12977
TM9SF3 transmembrane 9 superfamily member 3 -2.09845
ECHDC3 enoyl CoA hydratase domain containing 3 -2.03955
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.03806