CRCGN009_HEPG2_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo-p-dioxin 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN009_HEPG2_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.61207
MAP7 microtubule-associated protein 7 6.54497
STIMATE STIM activating enhancer 5.43909
CHMP6 charged multivesicular body protein 6 5.34522
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.07566
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.39473
NOTCH1 notch 1 4.09185
RPL39L ribosomal protein L39-like 4.07136
HDGFL3 HDGF like 3 3.97029
SQOR sulfide quinone oxidoreductase 3.51058
CBR3 carbonyl reductase 3 3.36523
SATB1 SATB homeobox 1 3.11156
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.0308
GPATCH8 G patch domain containing 8 2.95421
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.90409
GATA2 GATA binding protein 2 2.64488
GPER1 G protein-coupled estrogen receptor 1 2.5268
HEBP1 heme binding protein 1 2.49061
PLSCR3 phospholipid scramblase 3 2.42943
CHN1 chimerin 1 2.34808
DIPK1A divergent protein kinase domain 1A 2.27762
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.22415

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -4.62212
CHMP4B charged multivesicular body protein 4B -4.09606
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.7231
PEG10 paternally expressed 10 -3.58417
GNAS GNAS complex locus -3.35453
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.28611
ZMIZ1 zinc finger, MIZ-type containing 1 -2.99039
RNF167 ring finger protein 167 -2.84623
OXA1L oxidase (cytochrome c) assembly 1-like -2.61988
BIRC2 baculoviral IAP repeat containing 2 -2.15942
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.14275
CAB39 calcium binding protein 39 -2.04891