CRCGN009_HEPG2_24H:P13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 20.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN009_HEPG2_24H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 5.51276
LCN2 lipocalin 2 5.12668
MAP7 microtubule-associated protein 7 4.89454
CCDC92 coiled-coil domain containing 92 4.32915
MYLK myosin light chain kinase 3.9875
BACE2 beta-site APP-cleaving enzyme 2 3.7957
UBQLN2 ubiquilin 2 3.65783
AMDHD2 amidohydrolase domain containing 2 3.63525
DYNLT3 dynein, light chain, Tctex-type 3 3.39102
TMEM50A transmembrane protein 50A 3.3464
STIMATE STIM activating enhancer 3.30099
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.28888
PNKP polynucleotide kinase 3'-phosphatase 3.28534
CARMIL1 capping protein regulator and myosin 1 linker 1 3.28509
ASCC3 activating signal cointegrator 1 complex subunit 3 3.22988
HLA-DMA major histocompatibility complex, class II, DM alpha 3.18243
EPHB2 EPH receptor B2 3.16794
ANKRD10 ankyrin repeat domain 10 3.08752
DIPK1A divergent protein kinase domain 1A 2.8997
LPAR2 lysophosphatidic acid receptor 2 2.85995
HSPA1A heat shock 70kDa protein 1A 2.77811
ABHD6 abhydrolase domain containing 6 2.72291
TATDN2 TatD DNase domain containing 2 2.72089
KIF1B kinesin family member 1B 2.69359
MICALL1 MICAL-like 1 2.63268
UGDH UDP-glucose 6-dehydrogenase 2.6264
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.54965
INPP1 inositol polyphosphate-1-phosphatase 2.54215
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.44223
TULP4 tubby like protein 4 2.42522
RPA3 replication protein A3, 14kDa 2.40213
CHN1 chimerin 1 2.337
BIRC2 baculoviral IAP repeat containing 2 2.30737
H2BC9 H2B clustered histone 9 2.30147
TIMP2 TIMP metallopeptidase inhibitor 2 2.26282
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.23389
SKIC2 SKI2 subunit of superkiller complex 2.23139
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.19677
CAMKMT calmodulin-lysine N-methyltransferase 2.18237
TP53 tumor protein p53 2.15146
RPIA ribose 5-phosphate isomerase A 2.13562
SFTPB surfactant protein B 2.10162
WASF3 WAS protein family, member 3 2.05021
ANO10 anoctamin 10 2.04768

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.46672
LDHD lactate dehydrogenase D -6.90986
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.43365
GNAS GNAS complex locus -5.19836
PEG10 paternally expressed 10 -4.99736
TLR4 toll-like receptor 4 -4.43662
PCCB propionyl CoA carboxylase, beta polypeptide -4.42073
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.34341
TSPAN4 tetraspanin 4 -3.8433
ZNF586 zinc finger protein 586 -3.81464
FGFR4 fibroblast growth factor receptor 4 -3.80499
FASTKD5 FAST kinase domains 5 -3.64007
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.57299
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.55338
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.42721
CRELD2 cysteine-rich with EGF-like domains 2 -3.38384
HYOU1 hypoxia up-regulated 1 -3.15764
IER3 immediate early response 3 -3.01792
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.00412
NISCH nischarin -2.95964
MAPK13 mitogen-activated protein kinase 13 -2.92025
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.81304
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.74285
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.73041
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.6265
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.62427
PCNA proliferating cell nuclear antigen -2.58292
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.50643
PLA2G15 phospholipase A2, group XV -2.50372
CDK7 cyclin-dependent kinase 7 -2.38574
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.37444
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.32863
PRELID3B PRELI domain containing 3B -2.31684
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.31356
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.29467
CCNB1 cyclin B1 -2.29454
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.13784
STAMBP STAM binding protein -2.13663
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.12811
ADAMTSL3 ADAMTS-like 3 -2.12119
SQOR sulfide quinone oxidoreductase -2.09591
EGF epidermal growth factor -2.09579
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.08763
ARMCX1 armadillo repeat containing, X-linked 1 -2.08361
TFPI2 tissue factor pathway inhibitor 2 -2.07711
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05927
RERGL RERG/RAS-like -2.0516
ITGB1BP1 integrin beta 1 binding protein 1 -2.03918
EXT1 exostosin glycosyltransferase 1 -2.0381
ZFY zinc finger protein, Y-linked -2.03535
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.01947
FBXL12 F-box and leucine-rich repeat protein 12 -2.01603