CRCGN009_HEPG2_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 10.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN009_HEPG2_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.82494
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.44694
TATDN2 TatD DNase domain containing 2 4.429
GPER1 G protein-coupled estrogen receptor 1 4.14878
SLC75A1 solute carrier family 75 member 1 4.1477
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.13799
TIAM1 T-cell lymphoma invasion and metastasis 1 4.13098
TIMP2 TIMP metallopeptidase inhibitor 2 3.97968
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.78922
RPP38 ribonuclease P/MRP 38kDa subunit 3.66829
CHMP6 charged multivesicular body protein 6 3.54452
CBR3 carbonyl reductase 3 3.54151
STIMATE STIM activating enhancer 3.39247
EVL Enah/Vasp-like 3.27925
CCNA1 cyclin A1 3.17202
HLA-DMA major histocompatibility complex, class II, DM alpha 3.1297
SYNE2 spectrin repeat containing, nuclear envelope 2 3.09216
BACE2 beta-site APP-cleaving enzyme 2 3.04914
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.01468
CYCS cytochrome c, somatic 2.96943
CXCL2 chemokine (C-X-C motif) ligand 2 2.87153
PPARG peroxisome proliferator-activated receptor gamma 2.83778
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.82588
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.76033
HOXA10 homeobox A10 2.75716
TMEM50A transmembrane protein 50A 2.7295
H2BC12 H2B clustered histone 12 2.67169
ANKRD10 ankyrin repeat domain 10 2.65087
RXYLT1 ribitol xylosyltransferase 1 2.54387
TAC4 tachykinin 4 (hemokinin) 2.50425
KIF20A kinesin family member 20A 2.43085
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.40733
HDGFL3 HDGF like 3 2.31574
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.26323
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.23128
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.23084
CDPF1 cysteine-rich, DPF motif domain containing 1 2.22531
SQOR sulfide quinone oxidoreductase 2.19567
CCDC92 coiled-coil domain containing 92 2.0942
ZDHHC6 zinc finger, DHHC-type containing 6 2.08943
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.0776
ADAM10 ADAM metallopeptidase domain 10 2.06885
CDC45 cell division cycle 45 2.06139
PLSCR1 phospholipid scramblase 1 2.03113
TP53 tumor protein p53 2.00039

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.67196
CCNB2 cyclin B2 -7.52193
LDHD lactate dehydrogenase D -6.58098
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.51107
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.99952
OXA1L oxidase (cytochrome c) assembly 1-like -5.56297
MRPS2 mitochondrial ribosomal protein S2 -4.02526
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.95229
NT5DC2 5'-nucleotidase domain containing 2 -3.91878
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.79965
PLK1 polo-like kinase 1 -3.67741
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.66041
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.53421
ZNF586 zinc finger protein 586 -3.33474
ISOC1 isochorismatase domain containing 1 -3.22046
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.06278
ADI1 acireductone dioxygenase 1 -2.99161
NVL nuclear VCP-like -2.87269
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.78387
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.70473
PCCB propionyl CoA carboxylase, beta polypeptide -2.548
NRIP1 nuclear receptor interacting protein 1 -2.32133
MAVS mitochondrial antiviral signaling protein -2.31568
EGF epidermal growth factor -2.25253
TM9SF3 transmembrane 9 superfamily member 3 -2.21984
SNX5 sorting nexin 5 -2.20317
MYL9 myosin, light chain 9, regulatory -2.16097
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.15536
TLCD3A TLC domain containing 3A -2.12011
LCMT1 leucine carboxyl methyltransferase 1 -2.11214
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.09742
KNTC1 kinetochore associated 1 -2.0815
DKK3 dickkopf WNT signaling pathway inhibitor 3 -2.0463
PREB prolactin regulatory element binding -2.0279
PANK2 pantothenate kinase 2 -2.00187