CRCGN009_HEPG2_24H:P15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 5.16 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN009_HEPG2_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 4.85267
PNKP polynucleotide kinase 3'-phosphatase 3.54638
NOTCH1 notch 1 3.39745
CHMP6 charged multivesicular body protein 6 3.39397
LOC122526780 uncharacterized LOC122526780 3.3783
RPP38 ribonuclease P/MRP 38kDa subunit 3.17637
KLHL21 kelch-like family member 21 3.11951
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.04064
CARMIL1 capping protein regulator and myosin 1 linker 1 2.99722
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.96929
CXCL2 chemokine (C-X-C motif) ligand 2 2.88574
HLA-DMA major histocompatibility complex, class II, DM alpha 2.8124
SQOR sulfide quinone oxidoreductase 2.76018
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.72513
EPHA3 EPH receptor A3 2.49544
ADAM10 ADAM metallopeptidase domain 10 2.38984
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.28725
NKAPD1 NKAP domain containing 1 2.12465
PWWP3A PWWP domain containing 3A, DNA repair factor 2.05692

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.59096
PCNA proliferating cell nuclear antigen -6.5655
EGF epidermal growth factor -3.82637
OXA1L oxidase (cytochrome c) assembly 1-like -3.78221
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.70577
VAT1 vesicle amine transport 1 -3.50549
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.33662
LDHD lactate dehydrogenase D -3.23441
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.0903
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.07142
DNM1L dynamin 1-like -2.94757
TLR4 toll-like receptor 4 -2.63083
YME1L1 YME1-like 1 ATPase -2.51746
CSK c-src tyrosine kinase -2.43005
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.40391
POF1B premature ovarian failure, 1B -2.36149
PRPF4 pre-mRNA processing factor 4 -2.30454
CCNB2 cyclin B2 -2.27484
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.23768
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.15645
LHX6 LIM homeobox 6 -2.14029
CDKL3 cyclin-dependent kinase-like 3 -2.11006
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.08824
FAAP24 FA core complex associated protein 24 -2.08264
NFS1 NFS1 cysteine desulfurase -2.07356
GAN gigaxonin -2.06881
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.05665
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.0218
TXNDC9 thioredoxin domain containing 9 -2.01538
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.00722