CRCGN009_HEPG2_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 2.58 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN009_HEPG2_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.41882
SLC75A1 solute carrier family 75 member 1 4.97176
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.72547
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.52824
AMDHD2 amidohydrolase domain containing 2 4.50155
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.36891
PPARG peroxisome proliferator-activated receptor gamma 4.03819
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.70175
PRKCH protein kinase C, eta 3.54695
VGLL4 vestigial-like family member 4 3.08134
HEBP1 heme binding protein 1 2.93215
CCNF cyclin F 2.88713
GATA2 GATA binding protein 2 2.83467
PRR15L proline rich 15-like 2.81599
RXYLT1 ribitol xylosyltransferase 1 2.55409
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.52711
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.49564
TENT4A terminal nucleotidyltransferase 4A 2.46194
WDR7 WD repeat domain 7 2.31668
TRIM13 tripartite motif containing 13 2.24767
CCNA1 cyclin A1 2.21236
GPATCH8 G patch domain containing 8 2.20721
KIF20A kinesin family member 20A 2.15968
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.11679
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.07592
STK10 serine/threonine kinase 10 2.00095

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.64355
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.86932
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.43091
DNM1L dynamin 1-like -4.91291
CCDC86 coiled-coil domain containing 86 -4.46096
LDHD lactate dehydrogenase D -4.43912
FAIM Fas apoptotic inhibitory molecule -4.19601
TLR4 toll-like receptor 4 -3.66772
CCNB1 cyclin B1 -3.2233
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.19548
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.08512
NRIP1 nuclear receptor interacting protein 1 -2.67207
CXCL2 chemokine (C-X-C motif) ligand 2 -2.18674