CRCGN009_HEPG2_24H:P17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.30951
RPP38 ribonuclease P/MRP 38kDa subunit 6.9388
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.83373
E2F2 E2F transcription factor 2 4.79527
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.45641
LOC122526780 uncharacterized LOC122526780 4.13038
H2BC12 H2B clustered histone 12 4.08417
HLA-DMA major histocompatibility complex, class II, DM alpha 3.60022
CIAO3 cytosolic iron-sulfur assembly component 3 3.03678
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.92369
PPARG peroxisome proliferator-activated receptor gamma 2.91863
GPATCH8 G patch domain containing 8 2.88442
FOXJ3 forkhead box J3 2.76893
ADRB2 adrenoceptor beta 2, surface 2.76008
CDC45 cell division cycle 45 2.52538
GATA3 GATA binding protein 3 2.40473
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.19462
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.13
MEST mesoderm specific transcript 2.05995
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00954

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.59081
MAPK13 mitogen-activated protein kinase 13 -5.41111
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.24396
PCNA proliferating cell nuclear antigen -4.84842
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.44211
CSK c-src tyrosine kinase -3.9182
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.87009
ISOC1 isochorismatase domain containing 1 -3.76256
VAT1 vesicle amine transport 1 -3.55071
ADI1 acireductone dioxygenase 1 -3.49508
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.46711
KDM3A lysine (K)-specific demethylase 3A -3.42836
TWF2 twinfilin actin binding protein 2 -3.40785
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.36227
CCNB2 cyclin B2 -3.1463
CCDC86 coiled-coil domain containing 86 -3.13043
DERA deoxyribose-phosphate aldolase (putative) -3.10436
RAI14 retinoic acid induced 14 -2.85705
LYPLA1 lysophospholipase I -2.52636
PPOX protoporphyrinogen oxidase -2.26877
PHACTR4 phosphatase and actin regulator 4 -2.04309
GNAS GNAS complex locus -2.02725