| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | DMSO perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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76 genes differentially expressed following the CRCGN010_HEPG2_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYLK | myosin light chain kinase | 7.70417 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.38601 |
| ADRB2 | adrenoceptor beta 2, surface | 6.05854 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.55895 |
| STIMATE | STIM activating enhancer | 3.98772 |
| CSK | c-src tyrosine kinase | 3.97911 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.77796 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.59442 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 3.55737 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.50062 |
| NOTCH1 | notch 1 | 3.43522 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.3301 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.32894 |
| SATB1 | SATB homeobox 1 | 3.19229 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.97228 |
| TBP | TATA box binding protein | 2.88762 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.81468 |
| E2F2 | E2F transcription factor 2 | 2.78912 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.67851 |
| GATA3 | GATA binding protein 3 | 2.6642 |
| CHN1 | chimerin 1 | 2.6564 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.63375 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.62981 |
| MEST | mesoderm specific transcript | 2.58542 |
| LCN2 | lipocalin 2 | 2.54688 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.54313 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.51467 |
| CHMP6 | charged multivesicular body protein 6 | 2.48986 |
| CYCS | cytochrome c, somatic | 2.38816 |
| NOSIP | nitric oxide synthase interacting protein | 2.36353 |
| ZNF589 | zinc finger protein 589 | 2.35437 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.1964 |
| TMEM38B | transmembrane protein 38B | 2.18783 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.08513 |
| PIH1D1 | PIH1 domain containing 1 | 2.08455 |
| DMAC2 | distal membrane arm assembly component 2 | 2.07678 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.02289 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.01699 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.00251 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.00226 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -9.74963 |
| LDHD | lactate dehydrogenase D | -7.27249 |
| TLR4 | toll-like receptor 4 | -6.15066 |
| GLOD4 | glyoxalase domain containing 4 | -5.14655 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -5.13566 |
| CHMP4B | charged multivesicular body protein 4B | -5.07558 |
| SCAND1 | SCAN domain containing 1 | -4.93216 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.71999 |
| GNAS | GNAS complex locus | -4.67481 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.65928 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.42072 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.42025 |
| NGRN | neugrin, neurite outgrowth associated | -4.27544 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -4.11242 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.39777 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.33681 |
| TRAP1 | TNF receptor-associated protein 1 | -3.289 |
| BLVRA | biliverdin reductase A | -3.25183 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.99893 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.91943 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.79821 |
| FASTKD5 | FAST kinase domains 5 | -2.74093 |
| ADI1 | acireductone dioxygenase 1 | -2.72896 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.71997 |
| TWF2 | twinfilin actin binding protein 2 | -2.50698 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.39224 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.33856 |
| TRAPPC6A | trafficking protein particle complex 6A | -2.1873 |
| CCDC86 | coiled-coil domain containing 86 | -2.15913 |
| SNX11 | sorting nexin 11 | -2.13983 |
| CCNB1 | cyclin B1 | -2.12985 |
| MTFR1 | mitochondrial fission regulator 1 | -2.10971 |
| CAPN1 | calpain 1, (mu/I) large subunit | -2.1093 |
| CD320 | CD320 molecule | -2.10494 |
| TBCB | tubulin folding cofactor B | -2.05903 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.02815 |
