CRCGN010_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN010_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 7.236
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.08209
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.99264
RPL39L ribosomal protein L39-like 4.6692
CIAO3 cytosolic iron-sulfur assembly component 3 4.46563
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.34454
CBR3 carbonyl reductase 3 4.17195
ABHD4 abhydrolase domain containing 4 4.00519
CHN1 chimerin 1 3.77332
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.75842
UBQLN2 ubiquilin 2 3.663
MTERF3 mitochondrial transcription termination factor 3 3.50495
SNAP25 synaptosomal-associated protein, 25kDa 3.4638
MINDY1 MINDY lysine 48 deubiquitinase 1 3.15974
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.91262
ABHD6 abhydrolase domain containing 6 2.83003
PLS1 plastin 1 2.73213
ZNF589 zinc finger protein 589 2.72972
MEST mesoderm specific transcript 2.63686
E2F2 E2F transcription factor 2 2.53901
MCOLN1 mucolipin 1 2.43971
CNN3 calponin 3, acidic 2.3953
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.34957
PLSCR3 phospholipid scramblase 3 2.31386
KLHL9 kelch-like family member 9 2.26643
GARRE1 granule associated Rac and RHOG effector 1 2.13776
EVL Enah/Vasp-like 2.1093
BIRC2 baculoviral IAP repeat containing 2 2.09646
TEX10 testis expressed 10 2.06022

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.91515
ADI1 acireductone dioxygenase 1 -5.33579
OXA1L oxidase (cytochrome c) assembly 1-like -5.00253
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.60202
CD320 CD320 molecule -3.918
NGRN neugrin, neurite outgrowth associated -3.83124
DERA deoxyribose-phosphate aldolase (putative) -3.72537
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.68772
RPIA ribose 5-phosphate isomerase A -3.29972
CCNB2 cyclin B2 -3.09575
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.06512
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.0407
ARID5B AT rich interactive domain 5B (MRF1-like) -2.99518
SMNDC1 survival motor neuron domain containing 1 -2.99288
TLCD3A TLC domain containing 3A -2.70645
SLC35F2 solute carrier family 35, member F2 -2.70145
C2CD2 C2 calcium-dependent domain containing 2 -2.69309
IER3 immediate early response 3 -2.64047
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.53223
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.51948
TLR4 toll-like receptor 4 -2.50805
RBM34 RNA binding motif protein 34 -2.43703
LYPLA1 lysophospholipase I -2.38366
SCAND1 SCAN domain containing 1 -2.34614
DDIT4 DNA-damage-inducible transcript 4 -2.13583
TACC2 transforming, acidic coiled-coil containing protein 2 -2.09819
GNAS GNAS complex locus -2.09675
FBXL12 F-box and leucine-rich repeat protein 12 -2.0103