CRCGN010_HEPG2_24H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxyquinoline 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

104 genes differentially expressed following the CRCGN010_HEPG2_24H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP1 inositol polyphosphate-1-phosphatase 4.45341
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.44816
ZNF589 zinc finger protein 589 4.06417
ADGRE5 adhesion G protein-coupled receptor E5 3.93559
ZFP36 ZFP36 ring finger protein 3.91768
JADE2 jade family PHD finger 2 3.74912
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.65453
MTERF3 mitochondrial transcription termination factor 3 3.60763
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.46463
LOC122526780 uncharacterized LOC122526780 3.45256
STK10 serine/threonine kinase 10 3.42185
MYLK myosin light chain kinase 3.14913
ABHD4 abhydrolase domain containing 4 3.05916
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.05772
CDC45 cell division cycle 45 2.96588
CTSL cathepsin L 2.92211
CASC3 cancer susceptibility candidate 3 2.8737
CCL2 chemokine (C-C motif) ligand 2 2.83336
MVP major vault protein 2.80703
ANKRD10 ankyrin repeat domain 10 2.78554
AARS1 alanyl-tRNA synthetase 1 2.78408
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.70718
PPARG peroxisome proliferator-activated receptor gamma 2.69534
TRIB3 tribbles pseudokinase 3 2.6859
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.62041
HLA-DMA major histocompatibility complex, class II, DM alpha 2.61403
PFKL phosphofructokinase, liver 2.58148
SLC75A1 solute carrier family 75 member 1 2.57895
CYCS cytochrome c, somatic 2.5763
CSK c-src tyrosine kinase 2.53829
RAP1GAP RAP1 GTPase activating protein 2.51797
FOXO4 forkhead box O4 2.48762
MAP7 microtubule-associated protein 7 2.47394
PHGDH phosphoglycerate dehydrogenase 2.41321
TXNRD1 thioredoxin reductase 1 2.40923
SQOR sulfide quinone oxidoreductase 2.40526
CHMP6 charged multivesicular body protein 6 2.32326
SIK2 salt-inducible kinase 2 2.31233
KEAP1 kelch-like ECH-associated protein 1 2.31195
NNT nicotinamide nucleotide transhydrogenase 2.2864
CXCL2 chemokine (C-X-C motif) ligand 2 2.26702
CYB561 cytochrome b561 2.21087
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.18836
NISCH nischarin 2.18122
ZW10 zw10 kinetochore protein 2.15568
FOXA2 forkhead box A2 2.14172
LPAR2 lysophosphatidic acid receptor 2 2.10637
FBXO7 F-box protein 7 2.09152
MINDY1 MINDY lysine 48 deubiquitinase 1 2.08907
MBNL2 muscleblind-like splicing regulator 2 2.06891
NOSIP nitric oxide synthase interacting protein 2.03507
GPATCH8 G patch domain containing 8 2.03108
STAT5A signal transducer and activator of transcription 5A 2.02714
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.02658
PLS1 plastin 1 2.02557
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.01156
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.00608
IGF2R insulin-like growth factor 2 receptor 2.00061

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -8.18583
LDHD lactate dehydrogenase D -6.81573
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.43659
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.08793
ACOT9 acyl-CoA thioesterase 9 -3.62871
SOAT2 sterol O-acyltransferase 2 -3.5946
CCNB2 cyclin B2 -3.52662
DNM1L dynamin 1-like -3.4387
GLOD4 glyoxalase domain containing 4 -3.37828
CD320 CD320 molecule -3.29402
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.25146
HSPA1A heat shock 70kDa protein 1A -3.2385
PRPF4 pre-mRNA processing factor 4 -3.19899
HAT1 histone acetyltransferase 1 -3.08456
ALDOC aldolase C, fructose-bisphosphate -3.03996
TLR4 toll-like receptor 4 -2.91611
CRYZ crystallin, zeta (quinone reductase) -2.81452
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.76118
NRIP1 nuclear receptor interacting protein 1 -2.71158
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.69283
UBE2C ubiquitin-conjugating enzyme E2C -2.66399
TUBB6 tubulin, beta 6 class V -2.60821
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.54013
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.43344
MSH6 mutS homolog 6 -2.38979
SCAND1 SCAN domain containing 1 -2.37731
PLK1 polo-like kinase 1 -2.36395
ENOPH1 enolase-phosphatase 1 -2.35171
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.34665
CDC20 cell division cycle 20 -2.33154
THAP11 THAP domain containing 11 -2.31187
ISOC1 isochorismatase domain containing 1 -2.30418
RNF167 ring finger protein 167 -2.28875
SCML1 sex comb on midleg-like 1 (Drosophila) -2.28085
SLC35F2 solute carrier family 35, member F2 -2.21784
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.21417
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.1645
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.15408
ACAA1 acetyl-CoA acyltransferase 1 -2.14776
TFDP1 transcription factor Dp-1 -2.08974
SCML2 sex comb on midleg-like 2 (Drosophila) -2.06141
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.05857
PSRC1 proline/serine-rich coiled-coil 1 -2.04734
PCP4 Purkinje cell protein 4 -2.04047
TCEAL4 transcription elongation factor A (SII)-like 4 -2.03339
MRPL18 mitochondrial ribosomal protein L18 -2.00213