CRCGN010_HEPG2_24H:A10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxyquinoline 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN010_HEPG2_24H:A10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.16878
NOTCH1 notch 1 5.83168
SFTPB surfactant protein B 4.80241
MEST mesoderm specific transcript 4.55503
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.2115
CHN1 chimerin 1 3.94285
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.83123
LCN2 lipocalin 2 3.76859
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.6634
CSK c-src tyrosine kinase 3.57284
CXCL2 chemokine (C-X-C motif) ligand 2 3.55205
GPER1 G protein-coupled estrogen receptor 1 3.54315
PNKP polynucleotide kinase 3'-phosphatase 3.49509
RPL39L ribosomal protein L39-like 3.45168
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.3033
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.20893
UBQLN2 ubiquilin 2 3.09327
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.08896
BACE2 beta-site APP-cleaving enzyme 2 3.00921
HMOX1 heme oxygenase 1 2.99492
GSTZ1 glutathione S-transferase zeta 1 2.84978
AXIN1 axin 1 2.80648
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.64092
PRKCH protein kinase C, eta 2.51854
HLA-DMA major histocompatibility complex, class II, DM alpha 2.31307
LOC122526780 uncharacterized LOC122526780 2.24291
STXBP2 syntaxin binding protein 2 2.19052
MAP7 microtubule-associated protein 7 2.18268
FSD1 fibronectin type III and SPRY domain containing 1 2.17988
TSPAN6 tetraspanin 6 2.16284
MCUR1 mitochondrial calcium uniporter regulator 1 2.10608
DENND4B DENN/MADD domain containing 4B 2.08525
FES FES proto-oncogene, tyrosine kinase 2.08309
IFI30 interferon, gamma-inducible protein 30 2.02442

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.72687
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.31922
MAPK13 mitogen-activated protein kinase 13 -4.88293
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.08376
TLCD3A TLC domain containing 3A -4.06502
RAI14 retinoic acid induced 14 -4.01387
PEG10 paternally expressed 10 -3.68039
KDM3A lysine (K)-specific demethylase 3A -3.63605
SLC35F2 solute carrier family 35, member F2 -3.56234
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.31305
CCNB2 cyclin B2 -3.1825
SNX11 sorting nexin 11 -3.16779
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.14618
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.0312
CDC20 cell division cycle 20 -2.75313
PCCB propionyl CoA carboxylase, beta polypeptide -2.72287
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.52691
CCDC86 coiled-coil domain containing 86 -2.46339
DDIT4 DNA-damage-inducible transcript 4 -2.43282
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.27192
BLMH bleomycin hydrolase -2.25705
EIF5 eukaryotic translation initiation factor 5 -2.16915
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.04923
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.0479
AKAP12 A kinase (PRKA) anchor protein 12 -2.04456