CRCGN010_HEPG2_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorobenzene 2.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN010_HEPG2_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KCNK1 potassium channel, two pore domain subfamily K, member 1 7.30351
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.41224
CSK c-src tyrosine kinase 5.25856
GPER1 G protein-coupled estrogen receptor 1 5.05284
CXCL2 chemokine (C-X-C motif) ligand 2 4.24574
DYNLT3 dynein, light chain, Tctex-type 3 4.18001
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.15894
ADGRE5 adhesion G protein-coupled receptor E5 4.1508
STK10 serine/threonine kinase 10 3.91135
SNAP25 synaptosomal-associated protein, 25kDa 3.89778
MAP7 microtubule-associated protein 7 3.81685
BAX BCL2-associated X protein 3.68785
E2F2 E2F transcription factor 2 3.45739
MICALL1 MICAL-like 1 3.35725
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.29142
LOC122526780 uncharacterized LOC122526780 3.15969
DIPK1A divergent protein kinase domain 1A 2.97746
EVL Enah/Vasp-like 2.92699
KLHL9 kelch-like family member 9 2.88633
HLA-DMA major histocompatibility complex, class II, DM alpha 2.87019
H2BC12 H2B clustered histone 12 2.86353
ATP11B ATPase, class VI, type 11B 2.75083
SNX7 sorting nexin 7 2.74488
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.73042
TLN1 talin 1 2.48235
NUP133 nucleoporin 133kDa 2.48151
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.42429
C2CD2 C2 calcium-dependent domain containing 2 2.3307
GPATCH8 G patch domain containing 8 2.14264
GRWD1 glutamate-rich WD repeat containing 1 2.09996
CDC45 cell division cycle 45 2.07559
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.03531
XYLT2 xylosyltransferase II 2.00903

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -6.37396
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.67611
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.12053
OXA1L oxidase (cytochrome c) assembly 1-like -4.91016
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.66217
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.58602
TLCD3A TLC domain containing 3A -4.28008
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.25698
ADI1 acireductone dioxygenase 1 -4.21571
PCNA proliferating cell nuclear antigen -3.91281
ARID5B AT rich interactive domain 5B (MRF1-like) -3.66893
DDIT4 DNA-damage-inducible transcript 4 -3.47504
MAPK13 mitogen-activated protein kinase 13 -3.45385
LDHD lactate dehydrogenase D -3.43911
CCNB2 cyclin B2 -3.37575
DCK deoxycytidine kinase -3.29757
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.16511
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.14601
SPAG4 sperm associated antigen 4 -2.9167
SPDEF SAM pointed domain containing ETS transcription factor -2.60571
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.52296
KLK5 kallikrein-related peptidase 5 -2.49599
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -2.30581
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.30524
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.26413
KCTD2 potassium channel tetramerization domain containing 2 -2.25016
MT1F metallothionein 1F -2.21883
TCTN1 tectonic family member 1 -2.21727
NT5DC2 5'-nucleotidase domain containing 2 -2.2016
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.19484
HYOU1 hypoxia up-regulated 1 -2.15296
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.15273
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.13258
MT1E metallothionein 1E -2.10492
SIRT2 sirtuin 2 -2.08786
CLEC5A C-type lectin domain family 5, member A -2.08341
MT1G metallothionein 1G -2.06718
CRELD2 cysteine-rich with EGF-like domains 2 -2.0574
PILRB paired immunoglobin-like type 2 receptor beta -2.02393
PPT1 palmitoyl-protein thioesterase 1 -2.00963