CRCGN010_HEPG2_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorobenzene 1.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 6.85806
CCL2 chemokine (C-C motif) ligand 2 4.35121
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.20225
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.9943
STIMATE STIM activating enhancer 3.55688
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.46943
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.32783
CHMP6 charged multivesicular body protein 6 3.17152
RPP38 ribonuclease P/MRP 38kDa subunit 3.14852
GSTZ1 glutathione S-transferase zeta 1 3.11689
EVL Enah/Vasp-like 2.62577
ABHD6 abhydrolase domain containing 6 2.56849
PPARG peroxisome proliferator-activated receptor gamma 2.55106
AXIN1 axin 1 2.53259
MCM3 minichromosome maintenance complex component 3 2.48591
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.43664
TRIM13 tripartite motif containing 13 2.39348
KIF5C kinesin family member 5C 2.38889
CXCL2 chemokine (C-X-C motif) ligand 2 2.34484
PEX11A peroxisomal biogenesis factor 11 alpha 2.2503
FZD1 frizzled class receptor 1 2.20611
WDR73 WD repeat domain 73 2.19828
LSR lipolysis stimulated lipoprotein receptor 2.19651
JADE2 jade family PHD finger 2 2.15819
GATA3 GATA binding protein 3 2.0402

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -6.47808
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.92343
GOLT1B golgi transport 1B -4.37915
C2CD5 C2 calcium-dependent domain containing 5 -4.36658
SLC35F2 solute carrier family 35, member F2 -4.16361
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.16153
GNAS GNAS complex locus -4.07202
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.94717
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.88505
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.87724
VAT1 vesicle amine transport 1 -3.7838
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.67904
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.4798
TLR4 toll-like receptor 4 -3.45787
ADI1 acireductone dioxygenase 1 -3.38276
ZNF586 zinc finger protein 586 -3.37915
PCNA proliferating cell nuclear antigen -3.33794
ITGB1BP1 integrin beta 1 binding protein 1 -3.25417
CAB39 calcium binding protein 39 -3.23448
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.18033
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.08206
MRPS2 mitochondrial ribosomal protein S2 -2.92224
NT5DC2 5'-nucleotidase domain containing 2 -2.79618
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.76594
YME1L1 YME1-like 1 ATPase -2.64157
DERA deoxyribose-phosphate aldolase (putative) -2.59317
CDC25B cell division cycle 25B -2.56516
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.45096
HMG20B high mobility group 20B -2.3694
CCNB2 cyclin B2 -2.36607
TERF2IP telomeric repeat binding factor 2, interacting protein -2.3206
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.29798
TLCD3A TLC domain containing 3A -2.25993
MAPK13 mitogen-activated protein kinase 13 -2.25277
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.24679
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.19744
CCNB1 cyclin B1 -2.19077
ZMIZ1 zinc finger, MIZ-type containing 1 -2.10686