CRCGN010_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorobenzene 0.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

110 genes differentially expressed following the CRCGN010_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.42171
ADGRE5 adhesion G protein-coupled receptor E5 6.06738
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.82185
CYCS cytochrome c, somatic 4.57642
CCDC85B coiled-coil domain containing 85B 4.30869
VGLL4 vestigial-like family member 4 4.21287
GPATCH8 G patch domain containing 8 4.08055
BLMH bleomycin hydrolase 4.0155
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.86956
HOXA10 homeobox A10 3.77559
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.67864
UBQLN2 ubiquilin 2 3.61829
LCN2 lipocalin 2 3.56657
ABHD4 abhydrolase domain containing 4 3.55333
CIAO3 cytosolic iron-sulfur assembly component 3 3.55066
GSTZ1 glutathione S-transferase zeta 1 3.54665
PPARG peroxisome proliferator-activated receptor gamma 3.53556
STIMATE STIM activating enhancer 3.32162
ZNF589 zinc finger protein 589 3.18093
NMU neuromedin U 3.16457
HSPA1A heat shock 70kDa protein 1A 3.16188
DYNLT3 dynein, light chain, Tctex-type 3 3.14618
IDE insulin-degrading enzyme 3.04968
JADE2 jade family PHD finger 2 3.04923
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.03482
CARMIL1 capping protein regulator and myosin 1 linker 1 2.98666
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.94833
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.72144
GPER1 G protein-coupled estrogen receptor 1 2.71923
FZD7 frizzled class receptor 7 2.70992
PMM2 phosphomannomutase 2 2.70677
COPS7A COP9 signalosome subunit 7A 2.62266
CCL2 chemokine (C-C motif) ligand 2 2.57087
TATDN2 TatD DNase domain containing 2 2.53565
ALDOC aldolase C, fructose-bisphosphate 2.42269
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.40982
KCTD11 potassium channel tetramerization domain containing 11 2.39625
PTK2 protein tyrosine kinase 2 2.36576
GATA2 GATA binding protein 2 2.36271
KIF11 kinesin family member 11 2.3564
CXCR4 chemokine (C-X-C motif) receptor 4 2.35271
ZNF185 zinc finger protein 185 (LIM domain) 2.31321
CHN1 chimerin 1 2.3061
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.30288
DCHS2 dachsous cadherin-related 2 2.24383
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.2212
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.20476
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.20173
LPAR2 lysophosphatidic acid receptor 2 2.19297
PARP11 poly (ADP-ribose) polymerase family, member 11 2.17131
NLRX1 NLR family member X1 2.15248
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.13931
CRCT1 cysteine-rich C-terminal 1 2.1249
KDM5A lysine (K)-specific demethylase 5A 2.10251
LOC128966622 putative protein N-methyltransferase FAM86B2 2.08642
CBX4 chromobox homolog 4 2.07944
DNASE1L2 deoxyribonuclease I-like 2 2.07782
BAD BCL2-associated agonist of cell death 2.07765
PAX7 paired box 7 2.06516
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.05395
TEX10 testis expressed 10 2.04689
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.04331
PYGM phosphorylase, glycogen, muscle 2.04082
CLCN2 chloride channel, voltage-sensitive 2 2.03537
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.02451
BMAL2 basic helix-loop-helix ARNT like 2 2.02142
CBX8 chromobox homolog 8 2.00288

decreased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 -6.89487
OXA1L oxidase (cytochrome c) assembly 1-like -5.65519
ZNF586 zinc finger protein 586 -4.86744
ADI1 acireductone dioxygenase 1 -4.01898
TUBB6 tubulin, beta 6 class V -3.96472
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.84481
DNM1L dynamin 1-like -3.69738
LAP3 leucine aminopeptidase 3 -3.67109
SLC35F2 solute carrier family 35, member F2 -3.53869
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.40519
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.40048
FASTKD5 FAST kinase domains 5 -3.32159
CCNB1 cyclin B1 -3.29121
CCDC86 coiled-coil domain containing 86 -3.27614
CDC25B cell division cycle 25B -3.2512
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.24367
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.1689
ANKRD10 ankyrin repeat domain 10 -3.15308
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.06657
CCNB2 cyclin B2 -3.0485
RHEB Ras homolog enriched in brain -2.99711
TCERG1 transcription elongation regulator 1 -2.98917
FGFR4 fibroblast growth factor receptor 4 -2.90543
ITGB1BP1 integrin beta 1 binding protein 1 -2.80999
DSG2 desmoglein 2 -2.74189
PPOX protoporphyrinogen oxidase -2.6026
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.55637
WASHC4 WASH complex subunit 4 -2.49094
CPNE3 copine III -2.48073
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.36818
GOLT1B golgi transport 1B -2.36383
PCNA proliferating cell nuclear antigen -2.30405
PECR peroxisomal trans-2-enoyl-CoA reductase -2.2999
GNAS GNAS complex locus -2.29961
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.27499
EIF5 eukaryotic translation initiation factor 5 -2.24893
MYL9 myosin, light chain 9, regulatory -2.21879
FOS FBJ murine osteosarcoma viral oncogene homolog -2.20586
TBCB tubulin folding cofactor B -2.12579
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.12408
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.08043
GLOD4 glyoxalase domain containing 4 -2.06798
ACVR2A activin A receptor, type IIA -2.04417