CRCGN010_HEPG2_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc blue no. 2 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN010_HEPG2_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.02006
ADGRE5 adhesion G protein-coupled receptor E5 4.19819
RXYLT1 ribitol xylosyltransferase 1 3.83576
MYLK myosin light chain kinase 3.73759
EPHB2 EPH receptor B2 3.66448
NOTCH1 notch 1 3.59131
NMU neuromedin U 3.33717
CSK c-src tyrosine kinase 3.32942
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.31534
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.28655
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.28264
RRAGA Ras-related GTP binding A 3.22297
PNKP polynucleotide kinase 3'-phosphatase 3.09402
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.97774
STK10 serine/threonine kinase 10 2.89675
MEST mesoderm specific transcript 2.81736
ANO10 anoctamin 10 2.63995
CYCS cytochrome c, somatic 2.57725
FZD7 frizzled class receptor 7 2.5229
PMM2 phosphomannomutase 2 2.51832
NOSIP nitric oxide synthase interacting protein 2.41206
DIPK1A divergent protein kinase domain 1A 2.41093
LPAR2 lysophosphatidic acid receptor 2 2.34708
HLA-DMA major histocompatibility complex, class II, DM alpha 2.33069
ABHD6 abhydrolase domain containing 6 2.2855
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.16123
CHEK2 checkpoint kinase 2 2.14575
LOC122526780 uncharacterized LOC122526780 2.09262

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.64347
TLCD3A TLC domain containing 3A -7.13384
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.73353
VDAC1 voltage-dependent anion channel 1 -3.69226
RNF167 ring finger protein 167 -3.58446
NUP93 nucleoporin 93kDa -3.55455
MRPS2 mitochondrial ribosomal protein S2 -3.52684
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.47451
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.38164
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.36385
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.16294
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.10862
ACOT9 acyl-CoA thioesterase 9 -3.10655
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.04837
SLC35F2 solute carrier family 35, member F2 -3.02851
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.02515
C2CD5 C2 calcium-dependent domain containing 5 -2.98804
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.91644
LDHD lactate dehydrogenase D -2.67552
TM9SF2 transmembrane 9 superfamily member 2 -2.64423
ZNF274 zinc finger protein 274 -2.52268
ZNF84 zinc finger protein 84 -2.34874
STAT1 signal transducer and activator of transcription 1, 91kDa -2.34035
DCK deoxycytidine kinase -2.28456
ZNF222 zinc finger protein 222 -2.2198
GNAS GNAS complex locus -2.19625
TBCB tubulin folding cofactor B -2.15977
MACF1 microtubule-actin crosslinking factor 1 -2.13115
CAPNS1 calpain, small subunit 1 -2.07403
ZNF140 zinc finger protein 140 -2.03372
ZNF134 zinc finger protein 134 -2.02637
PDCD5 programmed cell death 5 -2.01314
ZNF268 zinc finger protein 268 -2.01279