CRCGN010_HEPG2_24H:A21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc blue no. 2 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN010_HEPG2_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 9.97566
CHN1 chimerin 1 4.70171
STK10 serine/threonine kinase 10 4.38313
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.03561
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.00687
PRR15L proline rich 15-like 3.96508
CSK c-src tyrosine kinase 3.9506
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.86701
CIAO3 cytosolic iron-sulfur assembly component 3 3.6491
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.53067
FHL2 four and a half LIM domains 2 3.41403
LPAR2 lysophosphatidic acid receptor 2 3.34372
MAP7 microtubule-associated protein 7 3.14701
TRIM13 tripartite motif containing 13 3.13362
PFKL phosphofructokinase, liver 2.97349
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.63392
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.6311
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.6238
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.5601
SATB1 SATB homeobox 1 2.4775
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.35817
NOTCH1 notch 1 2.31955
CDT1 chromatin licensing and DNA replication factor 1 2.31281
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.18633
TGFB3 transforming growth factor, beta 3 2.16387
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.16091
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.15687
TEX10 testis expressed 10 2.15318
PCDHB11 protocadherin beta 11 2.1517
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.11939
FBXL6 F-box and leucine-rich repeat protein 6 2.11509
FRS2 fibroblast growth factor receptor substrate 2 2.10594
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.10452
PMM2 phosphomannomutase 2 2.10305
TRAPPC10 trafficking protein particle complex 10 2.09957
CBR3 carbonyl reductase 3 2.09527
NVL nuclear VCP-like 2.04704

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -8.01603
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.05084
SLC35F2 solute carrier family 35, member F2 -4.19528
GNAS GNAS complex locus -4.12616
WASHC4 WASH complex subunit 4 -3.94192
RPN1 ribophorin I -3.82662
NRIP1 nuclear receptor interacting protein 1 -3.65237
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.56048
PCNA proliferating cell nuclear antigen -3.40857
CCNB2 cyclin B2 -3.35111
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.29902
KDM3A lysine (K)-specific demethylase 3A -3.22672
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.88112
TSPAN4 tetraspanin 4 -2.82379
MRPS2 mitochondrial ribosomal protein S2 -2.79223
CCDC86 coiled-coil domain containing 86 -2.48822
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.47104
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.37023
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.33849
CCNB1 cyclin B1 -2.26259
USP6NL USP6 N-terminal like -2.14652
VDAC1 voltage-dependent anion channel 1 -2.12089
PGRMC1 progesterone receptor membrane component 1 -2.07101