CRCGN010_HEPG2_24H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc blue no. 2 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN010_HEPG2_24H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 8.36397
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.50606
MAP7 microtubule-associated protein 7 5.48662
MYLK myosin light chain kinase 5.08693
CSK c-src tyrosine kinase 4.99151
DYNLT3 dynein, light chain, Tctex-type 3 4.96951
PPARG peroxisome proliferator-activated receptor gamma 4.82065
CDPF1 cysteine-rich, DPF motif domain containing 1 4.55629
MEST mesoderm specific transcript 4.53443
CHMP6 charged multivesicular body protein 6 4.36832
RPP38 ribonuclease P/MRP 38kDa subunit 4.24641
TRIM13 tripartite motif containing 13 4.03735
RRAGA Ras-related GTP binding A 3.64114
CD40 CD40 molecule, TNF receptor superfamily member 5 3.49143
EVL Enah/Vasp-like 3.42651
GPATCH8 G patch domain containing 8 3.41632
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.32323
LCN2 lipocalin 2 3.29048
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.26259
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.25577
LPAR2 lysophosphatidic acid receptor 2 3.22172
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.11572
HSPA1A heat shock 70kDa protein 1A 2.89284
ABHD6 abhydrolase domain containing 6 2.84962
STK10 serine/threonine kinase 10 2.81228
PRR15L proline rich 15-like 2.7358
FHL2 four and a half LIM domains 2 2.62188
VPREB3 pre-B lymphocyte 3 2.52472
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.51698
KLHDC2 kelch domain containing 2 2.45712
APOD apolipoprotein D 2.44771
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.41401
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.3989
CXCL9 chemokine (C-X-C motif) ligand 9 2.35474
TRIM2 tripartite motif containing 2 2.33308
SMAD3 SMAD family member 3 2.32468
CCL24 chemokine (C-C motif) ligand 24 2.32317
OPRPN opiorphin prepropeptide 2.31042
NT5C 5', 3'-nucleotidase, cytosolic 2.29295
PMM2 phosphomannomutase 2 2.29063
EPHA3 EPH receptor A3 2.2809
ZHX2 zinc fingers and homeoboxes 2 2.26346
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.263
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.24734
KDM5A lysine (K)-specific demethylase 5A 2.24331
IRS1 insulin receptor substrate 1 2.21168
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.20362
SKIC2 SKI2 subunit of superkiller complex 2.16581
GPER1 G protein-coupled estrogen receptor 1 2.16526
MOB3B MOB kinase activator 3B 2.13503
CLIP2 CAP-GLY domain containing linker protein 2 2.1311
LTA lymphotoxin alpha 2.12847
IL12RB2 interleukin 12 receptor, beta 2 2.12837
CLEC4E C-type lectin domain family 4, member E 2.12524
IFNG interferon, gamma 2.12149
DUOX2 dual oxidase 2 2.11306
ITPKC inositol-trisphosphate 3-kinase C 2.11053
RALGDS ral guanine nucleotide dissociation stimulator 2.09501
SUMO4 small ubiquitin-like modifier 4 2.09426
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.08938
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.05532
SLAMF1 signaling lymphocytic activation molecule family member 1 2.04271
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.01554

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.46278
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.31424
KDM3A lysine (K)-specific demethylase 3A -8.28198
LDHD lactate dehydrogenase D -6.18526
TUBB6 tubulin, beta 6 class V -5.24902
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.09515
CCNB2 cyclin B2 -4.81464
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.79841
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.56608
TLCD3A TLC domain containing 3A -4.15391
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.14692
LYPLA1 lysophospholipase I -3.94544
MRPS2 mitochondrial ribosomal protein S2 -3.7961
ZW10 zw10 kinetochore protein -3.78941
SLC35F2 solute carrier family 35, member F2 -3.76824
GNAS GNAS complex locus -3.60737
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.52243
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.41889
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.29161
DERA deoxyribose-phosphate aldolase (putative) -3.22912
GADD45A growth arrest and DNA-damage-inducible, alpha -3.15842
GDF15 growth differentiation factor 15 -3.13735
HSPB1 heat shock 27kDa protein 1 -3.05436
PRPF4 pre-mRNA processing factor 4 -3.05107
OXA1L oxidase (cytochrome c) assembly 1-like -2.95627
RNF167 ring finger protein 167 -2.8889
PLA2G15 phospholipase A2, group XV -2.85561
CD58 CD58 molecule -2.81447
TCTN1 tectonic family member 1 -2.6462
ZNF134 zinc finger protein 134 -2.59761
ENDOG endonuclease G -2.5396
DSG2 desmoglein 2 -2.52655
FOS FBJ murine osteosarcoma viral oncogene homolog -2.44829
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.39845
GYG1 glycogenin 1 -2.3692
ETFB electron-transfer-flavoprotein, beta polypeptide -2.36682
FAM216A family with sequence similarity 216, member A -2.34709
ZNF26 zinc finger protein 26 -2.3021
FBXW2 F-box and WD repeat domain containing 2 -2.28941
SPAG4 sperm associated antigen 4 -2.28228
TCEAL4 transcription elongation factor A (SII)-like 4 -2.27445
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.19147
HYOU1 hypoxia up-regulated 1 -2.10273
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.08441
LDHA lactate dehydrogenase A -2.07592
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.06517
PMPCA peptidase (mitochondrial processing) alpha -2.03297
YIPF5 Yip1 domain family, member 5 -2.01308
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.00274
GYS1 glycogen synthase 1 (muscle) -2.00221