CRCGN010_HEPG2_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN010_HEPG2_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 7.76841
PNKP polynucleotide kinase 3'-phosphatase 7.15396
E2F2 E2F transcription factor 2 5.27017
CIAO3 cytosolic iron-sulfur assembly component 3 4.75615
ATP11B ATPase, class VI, type 11B 4.73534
CCL2 chemokine (C-C motif) ligand 2 4.28999
ZNF589 zinc finger protein 589 4.1191
EVL Enah/Vasp-like 4.0017
PEX11A peroxisomal biogenesis factor 11 alpha 3.98424
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.567
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.52902
PCDHB11 protocadherin beta 11 3.28677
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.90869
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.88435
RRAGA Ras-related GTP binding A 2.79824
CCNF cyclin F 2.79648
PLSCR3 phospholipid scramblase 3 2.74831
HLA-DRA major histocompatibility complex, class II, DR alpha 2.74722
JADE2 jade family PHD finger 2 2.67609
SATB1 SATB homeobox 1 2.6499
PRR15L proline rich 15-like 2.64562
BIRC2 baculoviral IAP repeat containing 2 2.60044
CHMP6 charged multivesicular body protein 6 2.60027
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.54996
TREX2 three prime repair exonuclease 2 2.50233
MAST2 microtubule associated serine/threonine kinase 2 2.49155
RNF170 ring finger protein 170 2.46823
RAB31 RAB31, member RAS oncogene family 2.33992
WT1 Wilms tumor 1 2.33016
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.32419
DMTF1 cyclin D binding myb-like transcription factor 1 2.31762
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.31707
HOXB8 homeobox B8 2.30061
APOB apolipoprotein B 2.26826
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.2274
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.1858
STK10 serine/threonine kinase 10 2.18491
CGRRF1 cell growth regulator with ring finger domain 1 2.1744
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.1687
ZNF7 zinc finger protein 7 2.127
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.12218
ANKRD40CL ANKRD40 C-terminal like 2.11051
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.10301
HMGN4 high mobility group nucleosomal binding domain 4 2.10175
LRRC14 leucine rich repeat containing 14 2.09879
TBXA2R thromboxane A2 receptor 2.0841
MAMLD1 mastermind-like domain containing 1 2.07212
CD96 CD96 molecule 2.06229
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.044
FOXD3 forkhead box D3 2.04305
GFI1 growth factor independent 1 transcription repressor 2.03558
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.03313
WDR4 WD repeat domain 4 2.02801
TIAM1 T-cell lymphoma invasion and metastasis 1 2.02327
ADAT1 adenosine deaminase, tRNA-specific 1 2.01556
RXFP3 relaxin/insulin-like family peptide receptor 3 2.00446
IL12RB1 interleukin 12 receptor, beta 1 2.00157
SPDL1 spindle apparatus coiled-coil protein 1 2.00127

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.92128
OXA1L oxidase (cytochrome c) assembly 1-like -6.08166
CTSD cathepsin D -5.60102
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.03319
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.82488
CCDC86 coiled-coil domain containing 86 -4.76801
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.67154
DNM1L dynamin 1-like -4.65898
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.31768
MAPK13 mitogen-activated protein kinase 13 -3.88106
GNAS GNAS complex locus -3.64081
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.34695
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.11791
ZNF586 zinc finger protein 586 -3.07946
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.94736
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.93171
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.88036
RNF167 ring finger protein 167 -2.76057
COG2 component of oligomeric golgi complex 2 -2.60236
ADI1 acireductone dioxygenase 1 -2.5651
NRIP1 nuclear receptor interacting protein 1 -2.55838
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.49341
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.30439
CD37 CD37 molecule -2.19917
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.1691
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.16877
TLR4 toll-like receptor 4 -2.13209
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.11011
NOP14 NOP14 nucleolar protein -2.09026
RABGAP1L RAB GTPase activating protein 1-like -2.06674
STC1 stanniocalcin 1 -2.02505
DIABLO diablo, IAP-binding mitochondrial protein -2.00629
SPAG4 sperm associated antigen 4 -2.0049