CRCGN010_HEPG2_24H:B05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN010_HEPG2_24H:B05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.56697
DENND2D DENN/MADD domain containing 2D 5.6349
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.14358
ZNF589 zinc finger protein 589 3.98027
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.7552
EVL Enah/Vasp-like 3.51319
DYNLT3 dynein, light chain, Tctex-type 3 3.45933
LOC122526780 uncharacterized LOC122526780 3.42529
PNKP polynucleotide kinase 3'-phosphatase 3.36457
IDE insulin-degrading enzyme 3.30225
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.13412
MINDY1 MINDY lysine 48 deubiquitinase 1 3.09026
TXNL4B thioredoxin-like 4B 3.0872
KLHL9 kelch-like family member 9 3.08343
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.03818
ADGRG1 adhesion G protein-coupled receptor G1 2.94949
FZD7 frizzled class receptor 7 2.9365
CCNF cyclin F 2.86494
GPATCH8 G patch domain containing 8 2.85751
TIAM1 T-cell lymphoma invasion and metastasis 1 2.79119
IFI44L interferon-induced protein 44-like 2.76805
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.67695
JADE2 jade family PHD finger 2 2.55763
MAST2 microtubule associated serine/threonine kinase 2 2.55318
CHN1 chimerin 1 2.55212
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.51711
USP18 ubiquitin specific peptidase 18 2.504
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.47098
HSPA8 heat shock 70kDa protein 8 2.43657
ISG15 ISG15 ubiquitin-like modifier 2.38526
PTK2 protein tyrosine kinase 2 2.32018
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.26213
ERAP2 endoplasmic reticulum aminopeptidase 2 2.2492
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.21459
IFI6 interferon, alpha-inducible protein 6 2.21192
NMU neuromedin U 2.19275
RSAD2 radical S-adenosyl methionine domain containing 2 2.18686
IFI44 interferon-induced protein 44 2.1415
IFI35 interferon-induced protein 35 2.08212
RIGI RNA sensor RIG-I 2.04976
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.04679
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.01029
ANKRD36C ankyrin repeat domain 36C 2.00843
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.00081

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.00613
LDHD lactate dehydrogenase D -6.22867
CCNB2 cyclin B2 -5.83277
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.20017
UGDH UDP-glucose 6-dehydrogenase -5.09671
HAT1 histone acetyltransferase 1 -5.09285
GLOD4 glyoxalase domain containing 4 -4.77338
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.55809
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.54538
NRIP1 nuclear receptor interacting protein 1 -4.39959
CHMP4B charged multivesicular body protein 4B -4.28161
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.91777
CD58 CD58 molecule -3.5201
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.44468
DNM1L dynamin 1-like -3.27722
CCDC86 coiled-coil domain containing 86 -3.19559
OXA1L oxidase (cytochrome c) assembly 1-like -3.09752
WASHC4 WASH complex subunit 4 -2.97647
SLC35F2 solute carrier family 35, member F2 -2.97267
SQSTM1 sequestosome 1 -2.63628
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.62289
TM9SF2 transmembrane 9 superfamily member 2 -2.49705
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.47656
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.45591
NMRK2 nicotinamide riboside kinase 2 -2.37244
TBX2 T-box 2 -2.3563
ARL2 ADP-ribosylation factor-like 2 -2.3016
ZMIZ1 zinc finger, MIZ-type containing 1 -2.27453
MAG myelin associated glycoprotein -2.14368
ROM1 retinal outer segment membrane protein 1 -2.07469
TMEM147 transmembrane protein 147 -2.07185
TCTN1 tectonic family member 1 -2.03596
SESN1 sestrin 1 -2.03483
VAMP7 vesicle-associated membrane protein 7 -2.00252