CRCGN010_HEPG2_24H:B06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN010_HEPG2_24H:B06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.51512
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.21269
CARMIL1 capping protein regulator and myosin 1 linker 1 6.16371
CBR3 carbonyl reductase 3 4.44464
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.24176
CDC45 cell division cycle 45 3.81074
EVL Enah/Vasp-like 3.67934
CYCS cytochrome c, somatic 3.40506
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.24722
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.13699
GSTZ1 glutathione S-transferase zeta 1 3.00823
UBQLN2 ubiquilin 2 2.99333
ADRB2 adrenoceptor beta 2, surface 2.94082
CHMP6 charged multivesicular body protein 6 2.91779
STK10 serine/threonine kinase 10 2.88239
MOK MOK protein kinase 2.82177
PNKP polynucleotide kinase 3'-phosphatase 2.8094
LOC122526780 uncharacterized LOC122526780 2.80403
MAP7 microtubule-associated protein 7 2.79409
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.72877
C2CD2 C2 calcium-dependent domain containing 2 2.67596
PEX11A peroxisomal biogenesis factor 11 alpha 2.59696
EGF epidermal growth factor 2.58252
KLHL9 kelch-like family member 9 2.55265
PPARG peroxisome proliferator-activated receptor gamma 2.53625
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.45667
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.43712
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.42641
TNIP1 TNFAIP3 interacting protein 1 2.31685
TENT4A terminal nucleotidyltransferase 4A 2.2251
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.20073
ABHD6 abhydrolase domain containing 6 2.177
MEST mesoderm specific transcript 2.15196
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.09493
IDE insulin-degrading enzyme 2.08174
CXCR4 chemokine (C-X-C motif) receptor 4 2.05594
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 2.03137
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.01459

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.42416
ZNF586 zinc finger protein 586 -5.41355
MAPK13 mitogen-activated protein kinase 13 -5.14913
HSPB1 heat shock 27kDa protein 1 -3.78402
OXA1L oxidase (cytochrome c) assembly 1-like -3.70719
UGDH UDP-glucose 6-dehydrogenase -3.61109
GOLT1B golgi transport 1B -3.54623
PEG10 paternally expressed 10 -3.25198
CCNB2 cyclin B2 -3.14614
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.12106
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.07178
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.0372
FGFR4 fibroblast growth factor receptor 4 -2.94214
SCAND1 SCAN domain containing 1 -2.90118
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.83714
GNAS GNAS complex locus -2.78982
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.77329
KDM3A lysine (K)-specific demethylase 3A -2.67943
CCDC86 coiled-coil domain containing 86 -2.67511
PCNA proliferating cell nuclear antigen -2.64222
SPAG4 sperm associated antigen 4 -2.23219
NGRN neugrin, neurite outgrowth associated -2.15888
WASHC4 WASH complex subunit 4 -2.047