CRCGN010_HEPG2_24H:B11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

122 genes differentially expressed following the CRCGN010_HEPG2_24H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 9.11421
BLMH bleomycin hydrolase 5.67261
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.12975
CIAO3 cytosolic iron-sulfur assembly component 3 4.70918
MYLK myosin light chain kinase 4.61171
AMDHD2 amidohydrolase domain containing 2 4.55859
MAMLD1 mastermind-like domain containing 1 4.40694
KLHL21 kelch-like family member 21 4.34588
STK10 serine/threonine kinase 10 4.29731
DYNLT3 dynein, light chain, Tctex-type 3 4.13194
HDGFL3 HDGF like 3 3.57155
VAV3 vav 3 guanine nucleotide exchange factor 3.494
SFTPB surfactant protein B 3.46438
NOSIP nitric oxide synthase interacting protein 3.38494
MEF2C myocyte enhancer factor 2C 3.14267
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.04181
MAP7 microtubule-associated protein 7 2.97756
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.93808
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.74295
CCNF cyclin F 2.70187
DNAH17 dynein, axonemal, heavy chain 17 2.67659
MICALL1 MICAL-like 1 2.65254
MTSS2 MTSS I-BAR domain containing 2 2.64299
DIPK1A divergent protein kinase domain 1A 2.61441
CORT cortistatin 2.59356
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.5764
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.54567
MNMIP1 manchette microtubule inner protein 1 2.53082
E2F8 E2F transcription factor 8 2.50866
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.4883
GPATCH8 G patch domain containing 8 2.42352
RBL1 retinoblastoma-like 1 2.41186
LPAR2 lysophosphatidic acid receptor 2 2.40387
ATP13A2 ATPase type 13A2 2.36502
PRDM13 PR domain containing 13 2.34317
FBXO41 F-box protein 41 2.334
SHCBP1 SHC SH2-domain binding protein 1 2.31927
RERGL RERG/RAS-like 2.31167
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.30837
GPER1 G protein-coupled estrogen receptor 1 2.30612
SLC35E2B solute carrier family 35, member E2B 2.28988
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.27877
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.22946
AFDN afadin, adherens junction formation factor 2.21302
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.21163
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.19529
HSFX2 heat shock transcription factor family, X linked 2 2.18441
SHB Src homology 2 domain containing adaptor protein B 2.17844
TRIM46 tripartite motif containing 46 2.17815
ICAM1 intercellular adhesion molecule 1 2.16772
KLHL29 kelch-like family member 29 2.16738
DLX6 distal-less homeobox 6 2.15538
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.14524
SSTR1 somatostatin receptor 1 2.13591
ONECUT2 one cut homeobox 2 2.12532
TMEM160 transmembrane protein 160 2.11483
KRT33B keratin 33B, type I 2.11063
MEST mesoderm specific transcript 2.10566
OXTR oxytocin receptor 2.10312
PACS1 phosphofurin acidic cluster sorting protein 1 2.09305
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.09152
CLSTN2 calsyntenin 2 2.09005
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.08373
RAPSN receptor-associated protein of the synapse 2.08029
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.0765
PDCD5 programmed cell death 5 2.06722
LIMK1 LIM domain kinase 1 2.06358
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.04701
NPPB natriuretic peptide B 2.04662
MIER2 mesoderm induction early response 1, family member 2 2.04257
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.03587
CAV3 caveolin 3 2.00893
CBR3 carbonyl reductase 3 2.00622
HPS5 Hermansky-Pudlak syndrome 5 2.00529

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CDC20 cell division cycle 20 -9.21223
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -9.20125
CCNB2 cyclin B2 -5.28407
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.97287
FBXL12 F-box and leucine-rich repeat protein 12 -4.96306
UGDH UDP-glucose 6-dehydrogenase -4.92011
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.70359
DSG2 desmoglein 2 -4.67762
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.49598
ADI1 acireductone dioxygenase 1 -4.37987
ACOT9 acyl-CoA thioesterase 9 -4.31063
CCNB1 cyclin B1 -4.18995
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.14946
PCNA proliferating cell nuclear antigen -4.06953
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.034
ZNF586 zinc finger protein 586 -3.78443
PTPRK protein tyrosine phosphatase, receptor type, K -3.61614
CHMP4B charged multivesicular body protein 4B -3.58073
MAPK13 mitogen-activated protein kinase 13 -3.49173
CTNND1 catenin (cadherin-associated protein), delta 1 -3.20228
PEG10 paternally expressed 10 -3.08692
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.00804
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.82963
LOC127933115 uncharacterized LOC127933115 -2.77662
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.62608
BDKRB2 bradykinin receptor B2 -2.47187
GDF15 growth differentiation factor 15 -2.45496
DET1 de-etiolated homolog 1 (Arabidopsis) -2.33482
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.33002
GPR183 G protein-coupled receptor 183 -2.28633
MRC1 mannose receptor, C type 1 -2.25355
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.17154
PARM1 prostate androgen-regulated mucin-like protein 1 -2.14839
OLFML2A olfactomedin-like 2A -2.12305
MRPL42 mitochondrial ribosomal protein L42 -2.12198
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.11631
DIXDC1 DIX domain containing 1 -2.09839
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.09084
PLPP3 phospholipid phosphatase 3 -2.08011
DSE dermatan sulfate epimerase -2.06923
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -2.06845
TOR3A torsin family 3, member A -2.05327
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.03887
TGFBI transforming growth factor, beta-induced, 68kDa -2.02682
VSTM4 V-set and transmembrane domain containing 4 -2.01958
PRPF4 pre-mRNA processing factor 4 -2.01501
CTSK cathepsin K -2.00169