CRCGN010_HEPG2_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN010_HEPG2_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 5.22126
MINDY1 MINDY lysine 48 deubiquitinase 1 4.77194
STIMATE STIM activating enhancer 4.32885
CIAO3 cytosolic iron-sulfur assembly component 3 4.001
ATP11B ATPase, class VI, type 11B 3.90398
PPARG peroxisome proliferator-activated receptor gamma 3.88296
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.80175
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.70317
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.6012
RPP38 ribonuclease P/MRP 38kDa subunit 3.43556
NMU neuromedin U 3.33383
EVL Enah/Vasp-like 3.18126
TREM1 triggering receptor expressed on myeloid cells 1 3.11162
BAD BCL2-associated agonist of cell death 3.03631
LPAR2 lysophosphatidic acid receptor 2 2.9098
DYNLT3 dynein, light chain, Tctex-type 3 2.78891
DUOX2 dual oxidase 2 2.78631
LCN2 lipocalin 2 2.7633
GSTZ1 glutathione S-transferase zeta 1 2.64666
CD40 CD40 molecule, TNF receptor superfamily member 5 2.62902
VGLL4 vestigial-like family member 4 2.50364
LOC122526780 uncharacterized LOC122526780 2.43833
CTSL cathepsin L 2.34803
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.26747
NINJ1 ninjurin 1 2.25244
EGF epidermal growth factor 2.15152
HOOK3 hook microtubule-tethering protein 3 2.13893
ZIM2 zinc finger, imprinted 2 2.13517
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.13302
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.12318
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.1028
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.08419
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.04681
CTSS cathepsin S 2.00867
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00541

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.15554
UGDH UDP-glucose 6-dehydrogenase -4.94591
CD320 CD320 molecule -4.76714
DSG2 desmoglein 2 -4.62062
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.61065
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.53795
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.99748
CCNB2 cyclin B2 -3.67853
CHMP4B charged multivesicular body protein 4B -3.57615
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.54557
ZNF586 zinc finger protein 586 -3.39074
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.30059
OXA1L oxidase (cytochrome c) assembly 1-like -3.25445
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.22554
SLC35F2 solute carrier family 35, member F2 -3.08126
TOR1A torsin family 1, member A (torsin A) -3.01773
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.84694
GNAS GNAS complex locus -2.70783
WASHC4 WASH complex subunit 4 -2.57016
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.49929
NDRG1 N-myc downstream regulated 1 -2.16809