CRCGN010_HEPG2_24H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

125 genes differentially expressed following the CRCGN010_HEPG2_24H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.24454
VAT1 vesicle amine transport 1 5.15443
TXNRD1 thioredoxin reductase 1 5.14386
CYCS cytochrome c, somatic 4.71861
SQOR sulfide quinone oxidoreductase 4.41537
PPARG peroxisome proliferator-activated receptor gamma 4.35779
MINDY1 MINDY lysine 48 deubiquitinase 1 4.29928
CNPY3 canopy FGF signaling regulator 3 4.27519
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.23499
ADGRE5 adhesion G protein-coupled receptor E5 4.13452
MVP major vault protein 4.02409
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.9782
AMDHD2 amidohydrolase domain containing 2 3.86329
RAP1GAP RAP1 GTPase activating protein 3.82912
LPAR2 lysophosphatidic acid receptor 2 3.82134
SQSTM1 sequestosome 1 3.6989
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.64808
UBQLN2 ubiquilin 2 3.60828
CSK c-src tyrosine kinase 3.57061
CDC45 cell division cycle 45 3.56839
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.52689
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.49436
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.4349
E2F2 E2F transcription factor 2 3.34915
EPHA3 EPH receptor A3 3.33937
PRKCH protein kinase C, eta 3.31072
NPDC1 neural proliferation, differentiation and control, 1 3.17546
CHN1 chimerin 1 3.11686
ZFP36 ZFP36 ring finger protein 3.08195
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.05459
NMU neuromedin U 3.03844
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.02487
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.97422
DYNLT3 dynein, light chain, Tctex-type 3 2.93699
GSTZ1 glutathione S-transferase zeta 1 2.90016
FOSL1 FOS-like antigen 1 2.88766
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.84085
PCDHB11 protocadherin beta 11 2.83632
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.81744
DSG2 desmoglein 2 2.79968
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.7962
ABHD4 abhydrolase domain containing 4 2.76104
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.74356
GATA3 GATA binding protein 3 2.70638
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.61552
MAP7 microtubule-associated protein 7 2.56761
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.55724
ZW10 zw10 kinetochore protein 2.53877
UGDH UDP-glucose 6-dehydrogenase 2.51046
CARMIL1 capping protein regulator and myosin 1 linker 1 2.49572
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.45345
TIMP2 TIMP metallopeptidase inhibitor 2 2.45114
INPP1 inositol polyphosphate-1-phosphatase 2.36711
HEBP1 heme binding protein 1 2.29928
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.23915
FHL5 four and a half LIM domains 5 2.18184
ATG3 autophagy related 3 2.16346
CD8A CD8a molecule 2.15084
TG thyroglobulin 2.14925
DUSP6 dual specificity phosphatase 6 2.14825
RALB v-ral simian leukemia viral oncogene homolog B 2.12247
LCN2 lipocalin 2 2.10602
NANOS3 nanos homolog 3 (Drosophila) 2.08613
AARS1 alanyl-tRNA synthetase 1 2.08341
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.06848
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.0595
GARS1 glycyl-tRNA synthetase 1 2.0439
PCSK2 proprotein convertase subtilisin/kexin type 2 2.03085
TIAM1 T-cell lymphoma invasion and metastasis 1 2.01488
NBEA neurobeachin 2.01462
HOOK2 hook microtubule-tethering protein 2 2.01361

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.32137
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.21189
TRIB3 tribbles pseudokinase 3 -5.62411
TLR4 toll-like receptor 4 -4.97346
CDC20 cell division cycle 20 -4.91204
AURKB aurora kinase B -4.40687
SMNDC1 survival motor neuron domain containing 1 -4.38723
NT5DC2 5'-nucleotidase domain containing 2 -4.34871
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.91317
HSPB1 heat shock 27kDa protein 1 -3.77461
PSRC1 proline/serine-rich coiled-coil 1 -3.63654
STMN1 stathmin 1 -3.60211
MRPS2 mitochondrial ribosomal protein S2 -3.32826
SLC35F2 solute carrier family 35, member F2 -3.26874
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.26634
LDHD lactate dehydrogenase D -3.21901
RFC2 replication factor C (activator 1) 2, 40kDa -3.15601
TCTN1 tectonic family member 1 -3.15562
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.14151
OXA1L oxidase (cytochrome c) assembly 1-like -3.13959
PLK1 polo-like kinase 1 -3.06298
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.04497
HAT1 histone acetyltransferase 1 -2.8835
CDK1 cyclin-dependent kinase 1 -2.86546
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.74511
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.69404
ZNF586 zinc finger protein 586 -2.69275
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.69215
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.6598
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.6391
DERA deoxyribose-phosphate aldolase (putative) -2.62358
WASHC4 WASH complex subunit 4 -2.62195
ADI1 acireductone dioxygenase 1 -2.57845
NUP37 nucleoporin 37kDa -2.53128
NOL11 nucleolar protein 11 -2.4183
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.39608
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.31375
COPS7A COP9 signalosome subunit 7A -2.26916
MRPL39 mitochondrial ribosomal protein L39 -2.24163
CCNA2 cyclin A2 -2.20208
USP6NL USP6 N-terminal like -2.19042
KIF14 kinesin family member 14 -2.18972
MSRA methionine sulfoxide reductase A -2.18341
CRELD2 cysteine-rich with EGF-like domains 2 -2.18192
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.14903
MTFR1 mitochondrial fission regulator 1 -2.14473
THAP11 THAP domain containing 11 -2.11591
ZMIZ1 zinc finger, MIZ-type containing 1 -2.11416
ALDOC aldolase C, fructose-bisphosphate -2.06906
TOP2A topoisomerase (DNA) II alpha 170kDa -2.04597
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.02569
BIRC5 baculoviral IAP repeat containing 5 -2.01944
ICAM3 intercellular adhesion molecule 3 -2.01243
TMEM97 transmembrane protein 97 -2.00099