CRCGN010_HEPG2_24H:B17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN010_HEPG2_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
GATA3 GATA binding protein 3 5.50056
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.19769
CXCL2 chemokine (C-X-C motif) ligand 2 4.03804
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.99541
CHMP6 charged multivesicular body protein 6 3.69017
STIMATE STIM activating enhancer 3.68822
CSK c-src tyrosine kinase 3.61402
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.61337
GPATCH8 G patch domain containing 8 3.57445
RRAGA Ras-related GTP binding A 3.51489
MAST2 microtubule associated serine/threonine kinase 2 3.31415
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.27575
HLA-DMA major histocompatibility complex, class II, DM alpha 3.18463
MYLK myosin light chain kinase 2.93712
ZFP36 ZFP36 ring finger protein 2.88396
ABHD6 abhydrolase domain containing 6 2.82424
LCN2 lipocalin 2 2.49668
MCUR1 mitochondrial calcium uniporter regulator 1 2.15293
PNKP polynucleotide kinase 3'-phosphatase 2.14481
NOTCH1 notch 1 2.12973
MAP7 microtubule-associated protein 7 2.05016
GSTZ1 glutathione S-transferase zeta 1 2.04154
SLC75A1 solute carrier family 75 member 1 2.03127

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.42454
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.49144
MAPK13 mitogen-activated protein kinase 13 -4.99662
ZMIZ1 zinc finger, MIZ-type containing 1 -4.7819
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.05984
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.98535
TRIB3 tribbles pseudokinase 3 -3.97327
ELAC2 elaC ribonuclease Z 2 -3.93172
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.88401
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.75166
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.64651
LDHD lactate dehydrogenase D -3.6454
UGDH UDP-glucose 6-dehydrogenase -3.60849
ZDHHC6 zinc finger, DHHC-type containing 6 -3.56527
DUSP6 dual specificity phosphatase 6 -3.53359
PEG10 paternally expressed 10 -3.52982
NRIP1 nuclear receptor interacting protein 1 -3.52612
DNM1L dynamin 1-like -3.49593
VDAC1 voltage-dependent anion channel 1 -3.33849
TLCD3A TLC domain containing 3A -3.33602
OXA1L oxidase (cytochrome c) assembly 1-like -3.23188
RGS2 regulator of G-protein signaling 2 -3.16959
SCAND1 SCAN domain containing 1 -3.05068
TLR4 toll-like receptor 4 -2.99066
C2CD5 C2 calcium-dependent domain containing 5 -2.65898
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.61659
YME1L1 YME1-like 1 ATPase -2.49889
PPOX protoporphyrinogen oxidase -2.39378
NUP85 nucleoporin 85kDa -2.39073
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.36753
CRELD2 cysteine-rich with EGF-like domains 2 -2.31518
USP6NL USP6 N-terminal like -2.24369
ZNF586 zinc finger protein 586 -2.23466
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 -2.16842
ADAM11 ADAM metallopeptidase domain 11 -2.14721
CDIP1 cell death-inducing p53 target 1 -2.11981
GRM4 glutamate receptor, metabotropic 4 -2.04567