CRCGN010_HEPG2_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitronaphthalene 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN010_HEPG2_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.574
MAP7 microtubule-associated protein 7 5.22659
MYLK myosin light chain kinase 3.84001
EPHB2 EPH receptor B2 3.68696
SNAP25 synaptosomal-associated protein, 25kDa 3.58854
CARMIL1 capping protein regulator and myosin 1 linker 1 3.38821
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.34745
CHN1 chimerin 1 3.25943
STIMATE STIM activating enhancer 3.21808
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.20086
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.19142
KLHL21 kelch-like family member 21 3.18738
CCL2 chemokine (C-C motif) ligand 2 3.13615
PRKCH protein kinase C, eta 2.76513
LOC122526780 uncharacterized LOC122526780 2.71597
HSPA8 heat shock 70kDa protein 8 2.46722
BPHL biphenyl hydrolase-like (serine hydrolase) 2.45074
NOSIP nitric oxide synthase interacting protein 2.23241
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.214
POPDC3 popeye domain containing 3 2.21043
RXYLT1 ribitol xylosyltransferase 1 2.14006
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.02335

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.48806
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.40069
MAPK13 mitogen-activated protein kinase 13 -5.25237
GNAS GNAS complex locus -4.22222
LAP3 leucine aminopeptidase 3 -3.71485
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.53846
THAP11 THAP domain containing 11 -3.34509
DSG2 desmoglein 2 -3.2942
TLR4 toll-like receptor 4 -3.26748
PCNA proliferating cell nuclear antigen -2.99619
MRPS2 mitochondrial ribosomal protein S2 -2.96738
CCNB2 cyclin B2 -2.93592
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.9169
FOS FBJ murine osteosarcoma viral oncogene homolog -2.40958
USP6NL USP6 N-terminal like -2.35362
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.21507
PPOX protoporphyrinogen oxidase -2.09825
HYOU1 hypoxia up-regulated 1 -2.07542
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.05657
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.02989