CRCGN010_HEPG2_24H:B23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitronaphthalene 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN010_HEPG2_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.76473
MEST mesoderm specific transcript 6.5736
CHMP6 charged multivesicular body protein 6 4.91838
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.86997
MOK MOK protein kinase 4.67953
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.67208
BPHL biphenyl hydrolase-like (serine hydrolase) 4.57605
NOTCH1 notch 1 4.45357
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.43656
CXCL2 chemokine (C-X-C motif) ligand 2 4.35902
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.29729
E2F2 E2F transcription factor 2 4.23184
RRAGA Ras-related GTP binding A 4.17067
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 4.08296
MAP3K4 mitogen-activated protein kinase kinase kinase 4 4.07041
PMM2 phosphomannomutase 2 3.99944
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.98015
GPER1 G protein-coupled estrogen receptor 1 3.92091
PRR15L proline rich 15-like 3.80994
TREM1 triggering receptor expressed on myeloid cells 1 3.75396
CXCR4 chemokine (C-X-C motif) receptor 4 3.68841
PEX11A peroxisomal biogenesis factor 11 alpha 3.66859
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.47858
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.24235
HOXA10 homeobox A10 3.00611
PEX13 peroxisomal biogenesis factor 13 2.92574
CD40 CD40 molecule, TNF receptor superfamily member 5 2.88047
CCNF cyclin F 2.82791
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.77436
FZD7 frizzled class receptor 7 2.64345
RAB21 RAB21, member RAS oncogene family 2.52523
RXYLT1 ribitol xylosyltransferase 1 2.47207
SELENOW selenoprotein W 2.4655
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.45677
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.31938
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.30101
GPSM2 G-protein signaling modulator 2 2.27174
NMU neuromedin U 2.26294
ACP2 acid phosphatase 2, lysosomal 2.24859
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.2386
KLK5 kallikrein-related peptidase 5 2.22018
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.21834
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.21531
DEFB126 defensin, beta 126 2.21471
FAM204A family with sequence similarity 204, member A 2.21186
ZBTB18 zinc finger and BTB domain containing 18 2.2076
CSPG4 chondroitin sulfate proteoglycan 4 2.20593
ASCL2 achaete-scute family bHLH transcription factor 2 2.17574
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.1644
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.16407
FSD1 fibronectin type III and SPRY domain containing 1 2.15456
SRPK3 SRSF protein kinase 3 2.14278
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.13062
QPCTL glutaminyl-peptide cyclotransferase-like 2.12369
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.11996
STK25 serine/threonine kinase 25 2.10432
NT5E 5'-nucleotidase, ecto (CD73) 2.09172
IRX4 iroquois homeobox 4 2.08214
EPHA4 EPH receptor A4 2.08211
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.0612
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05913
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.05711
BSN bassoon presynaptic cytomatrix protein 2.03623
EPPK1 epiplakin 1 2.03243
ANKRD34C ankyrin repeat domain 34C 2.02957
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.01166
PRPF3 pre-mRNA processing factor 3 2.01

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -9.26535
PCNA proliferating cell nuclear antigen -5.74397
RFC2 replication factor C (activator 1) 2, 40kDa -5.64333
GOLT1B golgi transport 1B -4.90241
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.88766
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.77285
UBE3C ubiquitin protein ligase E3C -4.75493
ADI1 acireductone dioxygenase 1 -4.74994
KDM3A lysine (K)-specific demethylase 3A -4.66286
CCDC86 coiled-coil domain containing 86 -4.6505
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.57101
COG7 component of oligomeric golgi complex 7 -4.44615
THAP11 THAP domain containing 11 -4.43069
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.25487
UGDH UDP-glucose 6-dehydrogenase -4.13536
GNAS GNAS complex locus -4.11731
ITGB1BP1 integrin beta 1 binding protein 1 -3.91499
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.64443
SNX11 sorting nexin 11 -3.59094
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.57207
RAI14 retinoic acid induced 14 -3.56917
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.52296
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.4185
TWF2 twinfilin actin binding protein 2 -3.13581
FBXL12 F-box and leucine-rich repeat protein 12 -3.03127
CD320 CD320 molecule -2.96926
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.87543
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.64243
TLR4 toll-like receptor 4 -2.6276
TLCD3A TLC domain containing 3A -2.58541
GPN1 GPN-loop GTPase 1 -2.5433
ANXA5 annexin A5 -2.51923
TIGAR TP53 induced glycolysis regulatory phosphatase -2.40667
EIF5 eukaryotic translation initiation factor 5 -2.33467
ZNF706 zinc finger protein 706 -2.33404
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.3195
WBP11 WW domain binding protein 11 -2.24439
S100A11 S100 calcium binding protein A11 -2.22268
RBM15B RNA binding motif protein 15B -2.19926
BOLA2B bolA family member 2B -2.186
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.18262
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.12956
GDE1 glycerophosphodiester phosphodiesterase 1 -2.11158
ATG101 autophagy related 101 -2.10963
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -2.10109
GCLM glutamate-cysteine ligase, modifier subunit -2.09593
MTMR14 myotubularin related protein 14 -2.05488
PRCC papillary renal cell carcinoma (translocation-associated) -2.0431
WASHC4 WASH complex subunit 4 -2.03229
YIPF5 Yip1 domain family, member 5 -2.02316
TUBA1B tubulin, alpha 1b -2.01267
TEX264 testis expressed 264 -2.01246
TBX2 T-box 2 -2.01094
RGS19 regulator of G-protein signaling 19 -2.00356