CRCGN010_HEPG2_24H:C01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN010_HEPG2_24H:C01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 10.0
ABHD4 abhydrolase domain containing 4 7.41408
UGDH UDP-glucose 6-dehydrogenase 5.90681
AXIN1 axin 1 5.30434
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.20759
KEAP1 kelch-like ECH-associated protein 1 4.64399
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.35567
HMOX1 heme oxygenase 1 4.189
TEX10 testis expressed 10 4.07134
MVP major vault protein 3.96648
CXCL2 chemokine (C-X-C motif) ligand 2 3.95207
NOTCH1 notch 1 3.94581
PNKP polynucleotide kinase 3'-phosphatase 3.82324
FOSL1 FOS-like antigen 1 3.67981
SQSTM1 sequestosome 1 3.54779
CBR1 carbonyl reductase 1 3.53319
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.50386
SQOR sulfide quinone oxidoreductase 3.39396
PIH1D1 PIH1 domain containing 1 3.38266
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.14855
MCOLN1 mucolipin 1 2.92993
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.87313
CSK c-src tyrosine kinase 2.7999
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.71887
RAP1GAP RAP1 GTPase activating protein 2.70904
GPC1 glypican 1 2.68599
HLA-DMA major histocompatibility complex, class II, DM alpha 2.67445
MAP7 microtubule-associated protein 7 2.67043
INPP1 inositol polyphosphate-1-phosphatase 2.64978
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.61589
WDR12 WD repeat domain 12 2.59577
PRR15L proline rich 15-like 2.53296
RRAGA Ras-related GTP binding A 2.4969
UCK2 uridine-cytidine kinase 2 2.45818
CYCS cytochrome c, somatic 2.414
ASCC3 activating signal cointegrator 1 complex subunit 3 2.39862
CAPN15 calpain 15 2.39326
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.35111
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.33913
GNPDA1 glucosamine-6-phosphate deaminase 1 2.32868
SMIM40 small integral membrane protein 40 2.32642
ADGRE5 adhesion G protein-coupled receptor E5 2.30549
PEX6 peroxisomal biogenesis factor 6 2.30314
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.28602
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.24709
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.22665
CNPY3 canopy FGF signaling regulator 3 2.21123
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.20344
CISD1 CDGSH iron sulfur domain 1 2.19828
TOMM34 translocase of outer mitochondrial membrane 34 2.17166
GPER1 G protein-coupled estrogen receptor 1 2.16503
NPDC1 neural proliferation, differentiation and control, 1 2.16466
MRPS2 mitochondrial ribosomal protein S2 2.14543
LRP10 low density lipoprotein receptor-related protein 10 2.14173
LCN2 lipocalin 2 2.1346
KLHL21 kelch-like family member 21 2.13024
FCGBP Fc fragment of IgG binding protein 2.09285
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.08389
CDC123 cell division cycle 123 2.05613
MED24 mediator complex subunit 24 2.0533
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.04225
BAG2 BCL2-associated athanogene 2 2.01671
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.01274
CTSL cathepsin L 2.00533
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.00026

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.03758
CCNB2 cyclin B2 -6.86609
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.47746
FGFR4 fibroblast growth factor receptor 4 -5.27363
PEG10 paternally expressed 10 -5.24623
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.91419
ZNF586 zinc finger protein 586 -4.6924
FBXL12 F-box and leucine-rich repeat protein 12 -4.46667
MYL9 myosin, light chain 9, regulatory -4.37321
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.3644
C5 complement component 5 -4.34526
PECR peroxisomal trans-2-enoyl-CoA reductase -4.11673
KDM3A lysine (K)-specific demethylase 3A -4.11588
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.81087
ACAA1 acetyl-CoA acyltransferase 1 -3.62393
SNX11 sorting nexin 11 -3.57529
RFC2 replication factor C (activator 1) 2, 40kDa -3.47234
DCK deoxycytidine kinase -3.21339
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.1342
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.05273
NISCH nischarin -2.97584
LDHD lactate dehydrogenase D -2.97007
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.96468
COPS7A COP9 signalosome subunit 7A -2.90674
ADI1 acireductone dioxygenase 1 -2.89449
PDZD2 PDZ domain containing 2 -2.88986
DDIT4 DNA-damage-inducible transcript 4 -2.84307
ZDHHC6 zinc finger, DHHC-type containing 6 -2.82851
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.82304
PLG plasminogen -2.81905
SPAG4 sperm associated antigen 4 -2.81719
COG4 component of oligomeric golgi complex 4 -2.81383
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.78724
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.76242
PPOX protoporphyrinogen oxidase -2.74155
ZMIZ1 zinc finger, MIZ-type containing 1 -2.73064
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.71286
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.69924
PIPOX pipecolic acid oxidase -2.69706
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.65369
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.58429
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.57238
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.55039
MAT1A methionine adenosyltransferase I, alpha -2.50897
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.47658
CFHR2 complement factor H-related 2 -2.46869
AMBP alpha-1-microglobulin/bikunin precursor -2.45947
IFI44L interferon-induced protein 44-like -2.44572
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.42777
FASTKD5 FAST kinase domains 5 -2.39944
GNAS GNAS complex locus -2.38881
WASHC4 WASH complex subunit 4 -2.38142
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.35359
TOP2A topoisomerase (DNA) II alpha 170kDa -2.34395
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.3321
LAP3 leucine aminopeptidase 3 -2.33082
STAT1 signal transducer and activator of transcription 1, 91kDa -2.28753
FBF1 Fas (TNFRSF6) binding factor 1 -2.28192
AQP9 aquaporin 9 -2.24042
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.22832
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.22291
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.21219
VTN vitronectin -2.19946
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.17729
RIDA reactive intermediate imine deaminase A homolog -2.16525
PLP1 proteolipid protein 1 -2.15496
TSPAN31 tetraspanin 31 -2.13464
SERINC5 serine incorporator 5 -2.12734
OXTR oxytocin receptor -2.11283
KLHDC2 kelch domain containing 2 -2.10198
IRF9 interferon regulatory factor 9 -2.09632
USP6NL USP6 N-terminal like -2.08721
ZFYVE21 zinc finger, FYVE domain containing 21 -2.08321
HPX hemopexin -2.07442
ZNF443 zinc finger protein 443 -2.06716
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.06266
PAH phenylalanine hydroxylase -2.04251
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.02943
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.01369
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.01221
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.00717