CRCGN010_HEPG2_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN010_HEPG2_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.65855
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.49578
TXNRD1 thioredoxin reductase 1 6.33696
LCN2 lipocalin 2 5.64826
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 5.38018
GSTZ1 glutathione S-transferase zeta 1 4.71544
ADGRE5 adhesion G protein-coupled receptor E5 4.45287
ABHD6 abhydrolase domain containing 6 4.23251
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.02026
CYCS cytochrome c, somatic 3.91631
CXCL2 chemokine (C-X-C motif) ligand 2 3.84235
RPP38 ribonuclease P/MRP 38kDa subunit 3.837
JADE2 jade family PHD finger 2 3.70576
MAMLD1 mastermind-like domain containing 1 3.45448
NOTCH1 notch 1 3.40995
ABHD4 abhydrolase domain containing 4 3.40987
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.39556
CXCR4 chemokine (C-X-C motif) receptor 4 3.29573
SFTPB surfactant protein B 3.27729
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.22901
EPHB2 EPH receptor B2 3.10901
TEX10 testis expressed 10 3.06287
AMDHD2 amidohydrolase domain containing 2 2.94498
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.9131
PPARG peroxisome proliferator-activated receptor gamma 2.90857
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.79125
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.76233
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.64258
DUOX2 dual oxidase 2 2.6347
ATP11B ATPase, class VI, type 11B 2.63108
LIN7A lin-7 homolog A (C. elegans) 2.55619
DIPK1A divergent protein kinase domain 1A 2.51148
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.49541
IDE insulin-degrading enzyme 2.46908
NANOS2 nanos homolog 2 (Drosophila) 2.4653
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.30896
KEAP1 kelch-like ECH-associated protein 1 2.29693
BLMH bleomycin hydrolase 2.24108
GPER1 G protein-coupled estrogen receptor 1 2.2126
CEP57 centrosomal protein 57kDa 2.205
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.1882
IL5 interleukin 5 2.17736
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.15722
CGRRF1 cell growth regulator with ring finger domain 1 2.05097
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.04865
IL24 interleukin 24 2.04669
TIAM1 T-cell lymphoma invasion and metastasis 1 2.04464
CIAO3 cytosolic iron-sulfur assembly component 3 2.00544

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.62681
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.49916
MRPS16 mitochondrial ribosomal protein S16 -4.41722
GOLT1B golgi transport 1B -4.31954
MAPK13 mitogen-activated protein kinase 13 -4.24162
HSPB1 heat shock 27kDa protein 1 -4.04926
KDM3A lysine (K)-specific demethylase 3A -4.02598
RFC2 replication factor C (activator 1) 2, 40kDa -3.97457
CCNB2 cyclin B2 -3.6549
CHMP4B charged multivesicular body protein 4B -3.63816
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.53461
CDC20 cell division cycle 20 -3.25937
LOC124907782 dual specificity protein phosphatase 22 -2.9344
TRAP1 TNF receptor-associated protein 1 -2.89917
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.88536
ZW10 zw10 kinetochore protein -2.87831
TMCO1 transmembrane and coiled-coil domains 1 -2.8187
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.6284
FAT1 FAT atypical cadherin 1 -2.53114
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.44908
FOXO4 forkhead box O4 -2.42464
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.3451
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.17013
LDHD lactate dehydrogenase D -2.11463
ZNF134 zinc finger protein 134 -2.09127
ITGB1BP1 integrin beta 1 binding protein 1 -2.05947
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.05143
TPBG trophoblast glycoprotein -2.02159
RND3 Rho family GTPase 3 -2.00848