CRCGN010_HEPG2_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN010_HEPG2_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 5.3689
NMU neuromedin U 5.14098
GATA3 GATA binding protein 3 3.86628
STIMATE STIM activating enhancer 3.82132
LPAR2 lysophosphatidic acid receptor 2 3.77314
CHN1 chimerin 1 3.38537
TREM1 triggering receptor expressed on myeloid cells 1 3.35884
NUP133 nucleoporin 133kDa 3.16228
C2CD2 C2 calcium-dependent domain containing 2 3.13937
PMM2 phosphomannomutase 2 3.10867
SOCS2 suppressor of cytokine signaling 2 2.90588
JADE2 jade family PHD finger 2 2.90456
PLSCR3 phospholipid scramblase 3 2.65241
VAV3 vav 3 guanine nucleotide exchange factor 2.61607
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.60746
GARRE1 granule associated Rac and RHOG effector 1 2.58107
TXNRD1 thioredoxin reductase 1 2.57882
VGLL4 vestigial-like family member 4 2.56548
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.55661
CD40 CD40 molecule, TNF receptor superfamily member 5 2.50631
CCNF cyclin F 2.50616
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.37483
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.31022
NPDC1 neural proliferation, differentiation and control, 1 2.15954
CTSL cathepsin L 2.1465
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.13692
TRIM13 tripartite motif containing 13 2.13086
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.05819
PRR15L proline rich 15-like 2.01438

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.1171
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.65494
ZMIZ1 zinc finger, MIZ-type containing 1 -6.08917
FGFR4 fibroblast growth factor receptor 4 -6.07211
OXA1L oxidase (cytochrome c) assembly 1-like -5.96916
VAT1 vesicle amine transport 1 -5.66911
PCNA proliferating cell nuclear antigen -3.36285
TCTN1 tectonic family member 1 -3.16328
SLC35F2 solute carrier family 35, member F2 -3.12612
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.86262
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.83847
FASTKD5 FAST kinase domains 5 -2.74422
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.54654
GAL3ST1 galactose-3-O-sulfotransferase 1 -2.27335
ACAA1 acetyl-CoA acyltransferase 1 -2.22584