CRCGN010_HEPG2_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN010_HEPG2_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.74858
LCN2 lipocalin 2 6.24757
MSRA methionine sulfoxide reductase A 5.1837
ADGRE5 adhesion G protein-coupled receptor E5 4.59481
NMU neuromedin U 4.5005
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.46315
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.37637
GPER1 G protein-coupled estrogen receptor 1 4.19828
GPATCH8 G patch domain containing 8 4.1203
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.02844
EPHB2 EPH receptor B2 3.81631
PPARG peroxisome proliferator-activated receptor gamma 3.71882
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.64068
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.61183
NOSIP nitric oxide synthase interacting protein 3.5597
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.43603
LYN LYN proto-oncogene, Src family tyrosine kinase 3.39119
TREM1 triggering receptor expressed on myeloid cells 1 3.22724
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.05309
STXBP2 syntaxin binding protein 2 2.94491
FZD7 frizzled class receptor 7 2.77145
HLA-DMA major histocompatibility complex, class II, DM alpha 2.7064
PFKL phosphofructokinase, liver 2.68196
ADGRG1 adhesion G protein-coupled receptor G1 2.63683
ZFP36 ZFP36 ring finger protein 2.6079
CRTAP cartilage associated protein 2.59583
HBA1 hemoglobin, alpha 1 2.58129
PMM2 phosphomannomutase 2 2.55352
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.53798
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.47253
HBB hemoglobin, beta 2.45919
LPAR2 lysophosphatidic acid receptor 2 2.34037
FABP6 fatty acid binding protein 6, ileal 2.33966
DPYSL3 dihydropyrimidinase-like 3 2.33939
PLBD1 phospholipase B domain containing 1 2.33875
MEST mesoderm specific transcript 2.28707
MAST2 microtubule associated serine/threonine kinase 2 2.26347
CHN1 chimerin 1 2.24555
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.21394
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.18045
FLNC filamin C, gamma 2.17834
SSBP2 single-stranded DNA binding protein 2 2.17448
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.14369
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.10617
NECTIN4 nectin cell adhesion molecule 4 2.10032
DVL3 dishevelled segment polarity protein 3 2.09326
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.08975
SUMO4 small ubiquitin-like modifier 4 2.03733

decreased expression

Symbol Name Standardized Value
CASP3 caspase 3, apoptosis-related cysteine peptidase -7.717
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.07683
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.27801
TSPAN4 tetraspanin 4 -4.21395
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.17428
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.14468
CDC20 cell division cycle 20 -3.88619
GNAS GNAS complex locus -3.8852
NRIP1 nuclear receptor interacting protein 1 -3.68955
MRPS2 mitochondrial ribosomal protein S2 -3.67684
COG7 component of oligomeric golgi complex 7 -3.62868
CHMP4B charged multivesicular body protein 4B -3.5674
UGDH UDP-glucose 6-dehydrogenase -3.4833
CCNB2 cyclin B2 -3.47351
PUF60 poly-U binding splicing factor 60KDa -3.46443
RNF167 ring finger protein 167 -3.42738
ZMIZ1 zinc finger, MIZ-type containing 1 -3.42377
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.17056
RFC2 replication factor C (activator 1) 2, 40kDa -2.97669
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.67374
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.62806
WDR7 WD repeat domain 7 -2.56023
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.52874
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.49766
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.38874
MAPK13 mitogen-activated protein kinase 13 -2.33834
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.27861
AURKB aurora kinase B -2.18044
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.14259
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.11151
KIF14 kinesin family member 14 -2.0613
PRPF4 pre-mRNA processing factor 4 -2.04993
ACOT13 acyl-CoA thioesterase 13 -2.02363