CRCGN010_HEPG2_24H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN010_HEPG2_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 6.23887
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.63762
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.57482
LOC122526780 uncharacterized LOC122526780 3.40274
MOK MOK protein kinase 3.35722
SATB1 SATB homeobox 1 3.16118
LCN2 lipocalin 2 3.09312
CCNA1 cyclin A1 2.99651
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.96277
PPARG peroxisome proliferator-activated receptor gamma 2.96046
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.95713
TREM1 triggering receptor expressed on myeloid cells 1 2.78767
EVL Enah/Vasp-like 2.78442
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.69398
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.56878
PRKCH protein kinase C, eta 2.49104
RAB21 RAB21, member RAS oncogene family 2.14391
GATA3 GATA binding protein 3 2.13827
BPHL biphenyl hydrolase-like (serine hydrolase) 2.12591
KLHL9 kelch-like family member 9 2.06401
NPDC1 neural proliferation, differentiation and control, 1 2.05903
RRAGA Ras-related GTP binding A 2.00242

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.58634
OXA1L oxidase (cytochrome c) assembly 1-like -4.65389
GNAS GNAS complex locus -4.64131
FBXL12 F-box and leucine-rich repeat protein 12 -4.41196
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.16494
TUBB6 tubulin, beta 6 class V -4.16044
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.94766
PLK1 polo-like kinase 1 -3.31829
TRIB3 tribbles pseudokinase 3 -3.273
DDIT4 DNA-damage-inducible transcript 4 -3.0525
C2CD5 C2 calcium-dependent domain containing 5 -2.87771
KDM3A lysine (K)-specific demethylase 3A -2.84484
CHMP4B charged multivesicular body protein 4B -2.7155
PCNA proliferating cell nuclear antigen -2.53997
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.49484
MVP major vault protein -2.16017
CAB39 calcium binding protein 39 -2.14278
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.10381
HMG20B high mobility group 20B -2.05521
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.00015